Evidence map›Paper›PMID 37781865›Full record

ArticleEuropean journal of histochemistry : EJH2023

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt).

Qingjing Gao, Wenqian Xie, Wenjing Lu, Yuning Liu, Haolin Zhang, Yingying Han, Qiang Weng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of histochemistry : EJH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qingjing GaoLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. gaoqingjing@bjfu.edu.cn.
Wenqian XieLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. xwq11@bjfu.edu.cn.
Wenjing LuLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. luwenjing@bjfu.edu.cn.
Yuning LiuLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. yuningliu9@bjfu.edu.cn.
Haolin ZhangLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. haolinzhang@bjfu.edu.cn.
Yingying HanLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. thinkinghyy@bjfu.edu.cn.
Qiang WengLaboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing. qiangweng@bjfu.edu.cn.
Beijing Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolactin (PRL) is a hormone crucial for normal reproduction, functioning as an autocrine, paracrine, and endocrine factor. This study aimed to examine the immunolocalization and expression patterns of PRL, prolactin receptor (PRLR), and signal transducer and activator of transcription 5 (STAT5) in the ovaries of wild ground squirrels during both breeding and non-breeding periods. Significant seasonal variations were observed in ovarian weights, with higher values during the breeding season and relatively lower values during the nonbreeding season. PRL, PRLR, STAT5, and p-STAT5 were immunolocalized in granulosa cells and luteal cells during the breeding season, whereas they were exclusively found in granulosa cells during the non-breeding season. The mRNA expression levels of Prl, Prlr, and Stat5 were increased in ovarian tissues during the breeding season compared to the non-breeding season. Moreover, the mean mRNA levels of Prl, Prlr, and Stat5 exhibited a positive correlation with ovarian weights. Both circulating PRL and ovarian PRL concentrations were significantly elevated during the breeding season. Additionally, transcriptomic analysis of ovarian tissues revealed differentially expressed genes possibly associated with ovarian function and mammary gland development, including ovarian follicle development, steroid synthesis, and regulation of reproductive process. These findings suggest that PRL might play an essential endocrine, autocrine, or paracrine role in the regulation of seasonal changes in the ovarian functions in wild ground squirrels.

Indexed as

ProlactinReceptors, ProlactinAnimalsFemaleOvaryRNA, MessengerSciuridaeSeasonsSTAT5 Transcription FactorProlactinReceptors, ProlactinRNA, MessengerSTAT5 Transcription Factor

Identifiers

PMID37781865
PMCPMC10614723
OpenAlexW4387241688

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.