Evidence map›Paper›PMID 37781861›Full record

ArticleDevelopment and psychopathology2023

Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.

Jinni Su, Sally I-Chun Kuo, Fazil Aliev, Jill A Rabinowitz, Belal Jamil, Grace Chan, Howard J Edenberg, Meredith Francis, Victor Hesselbrock, Chella Kamarajan and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development and psychopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 1 country.

Jinni SuDepartment of Psychology, Arizona State University, Tempe, AZ, USA.ORCID https://orcid.org/0000-0002-9767-1489
Sally I-Chun KuoDepartment of Psychiatry, Rutgers University, New Brunswick, NJ, USA.ORCID https://orcid.org/0000-0002-6192-1001
Fazil AlievDepartment of Psychiatry, Rutgers University, New Brunswick, NJ, USA.
Jill A RabinowitzBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Belal JamilDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
Grace ChanDepartment of Psychiatry, University of Connecticut, Farmington, CT, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Meredith FrancisDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut, Farmington, CT, USA.
Chella KamarajanDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, USA.
Sivan KinreichDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, USA.
John KramerDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Donbing LaiDepartment of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Vivia McCutcheonDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Jacquelyn MeyersDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, USA.
Ashwini PandeyDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, USA.
Gayathri PandeyDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, USA.ORCID https://orcid.org/0000-0003-0889-3117
Martin H PlaweckiDepartment of Psychiatry, Indiana University, Bloomington, IN, USA.
Marc SchuckitDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Jay TischfieldDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Danielle M DickRutgers Addiction Research Center, Rutgers University, New Brunswick, NJ, USA.
State University of New York · USRutgers, The State University of New Jersey · USArizona State University · USIndiana University – Purdue University Indianapolis · USUniversity of Iowa · USWashington University in St. Louis · USIndiana University Bloomington · USJohns Hopkins University · USUniversity of California San Diego · USUniversity of Connecticut · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
NIAAA NIH HHS U10 AA008401
6 · The paper itself

Abstract

Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.

Indexed as

alcohol useCOGAgene-environment interactionpolygenic scoressocial support

Identifiers

PMID37781861
PMCPMC10985050
OpenAlexW4387241173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.