Evidence map›Paper›PMID 37781681›Full record

ReviewRheumatology and immunology research2023

Peptide-based immunotherapy in lupus: Where are we now?

Ram P Singh, David S Bischoff, Satendra S Singh, Bevra H Hahn

Open access · diamondAbstract readReview
In one paragraph

Review in Rheumatology and immunology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ram P SinghResearch Service, Veteran Administration Greater Los Angeles Healthcare System, Los Angeles, 90073 CA, USA.ORCID https://orcid.org/0000-0002-3203-4454
David S BischoffResearch Service, Veteran Administration Greater Los Angeles Healthcare System, Los Angeles, 90073 CA, USA.
Satendra S SinghCedars-Sinai Medical Center, Beverly Hills, 90048 CA, USA.
Bevra H HahnDepartment of Medicine, University of California, Los Angeles, Los Angeles, 90095 CA, USA.
University of California, Los Angeles · USCedars-Sinai Medical Center · USVA Greater Los Angeles Healthcare System · US

Funding

Role of Sex Differences in the Expression & Function of Regulatory T cells in SLER21AI083894 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAM PYARE · 2009 to 2010
$424k
Molecular Basis of Suppression of SLE by CD8+ Ti CellsR21AI065645 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAM PYARE · 2007 to 2008
$229k
Delineating the Role of Selected Genes in Lupus Induced by CD8+Ti and CD4+CD25 TR03AR054034 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAM PYARE · 2007 to 2009
$228k
NIAID NIH HHS R21 AI065645NIAID NIH HHS R21 AI083894NIAMS NIH HHS R03 AR054034
6 · The paper itself

Abstract

In autoimmune rheumatic diseases, immune hyperactivity and chronic inflammation associate with immune dysregulation and the breakdown of immune self-tolerance. A continued, unresolved imbalance between effector and regulatory immune responses further exacerbates inflammation that ultimately causes tissue and organ damage. Many treatment modalities have been developed to restore the immune tolerance and immmunoregulatory balance in autoimmune rheumatic diseases, including the use of peptide-based therapeutics or the use of nanoparticles-based nanotechnology. This review summarizes the state-of-the-art therapeutic use of peptide-based therapies in autoimmune rheumatic diseases, with a specific focus on lupus.

Indexed as

chemokinecytokineimmune toleranceimmunotherapylupuspeptideregulatory T cells

Identifiers

PMID37781681
PMCPMC10538607
OpenAlexW4387142535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.