Evidence map›Paper›PMID 37781624›Full record

ArticlebioRxiv : the preprint server for biology2024

Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.

Sofia Beas, Isbah Khan, Claire Gao, Gabriel Loewinger, Emma Macdonald, Alison Bashford, Shakira Rodriguez-Gonzalez, Francisco Pereira, Mario A Penzo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sofia BeasUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0003-0196-7574
Isbah KhanUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Claire GaoUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Gabriel LoewingerMachine Learning Team, National Institute of Mental Health, Bethesda, MD, USA.
Emma MacdonaldUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Alison BashfordUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Shakira Rodriguez-GonzalezUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Francisco PereiraMachine Learning Team, National Institute of Mental Health, Bethesda, MD, USA.
Mario A PenzoUnit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.

Funding

Dissecting the stress circuits of the paraventricular nucleus of the thalamusZIAMH002950 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PENZO, MARIO · 2016 to 2025
$17.5M
Mapping Thalamo-striatal Neuronal Circuits Underlying Motivational DriveR00MH126429 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEAS, SOFIA · 2022 to 2024
$796k
Intramural NIH HHS ZIA MH002950NIMH NIH HHS R00 MH126429
6 · The paper itself

Abstract

The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process is thought to rely on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)

Identifiers

PMID37781624
PMCPMC10541145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.