Evidence map›Paper›PMID 37781615›Full record

ArticlebioRxiv : the preprint server for biology2023

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.

Haiyan Li, Megan Kuhn, Ruth A Kelly, Ayushi Singh, Kavipriya Kovai Palanivel, Izzy Salama, Michael L De Ieso, W Daniel Stamer, Preethi S Ganapathy, Samuel Herberg

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Haiyan LiDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Megan KuhnDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27708, USA.
Ruth A KellyDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27708, USA.
Ayushi SinghDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Kavipriya Kovai PalanivelDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Izzy SalamaDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Michael L De IesoDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27708, USA.
W Daniel StamerDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27708, USA.
Preethi S GanapathyDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Samuel HerbergDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
SUNY Upstate Medical University · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathologic alterations in the biomechanical properties of the Schlemm's canal (SC) inner wall endothelium and its immediate vicinity are strongly associated with ocular hypertension in glaucoma due to decreased outflow facility. Specifically, the underlying trabecular meshwork is substantially stiffer in glaucomatous eyes compared to that from normal eyes. This raises the possibility of a critical involvement of mechanotransduction processes in driving SC cell dysfunction. Yes-associated protein (YAP) has emerged as a key contributor to glaucoma pathogenesis. However, the molecular underpinnings of SC cell YAP mechanosignaling in response to glaucomatous extracellular matrix (ECM) stiffening are not well understood. Using a novel biopolymer hydrogel that facilitates dynamic and reversible stiffness tuning, we investigated how ECM stiffening modulates YAP activity in primary human SC cells, and whether disruption of YAP mechanosignaling attenuates SC cell pathobiology and increases

Indexed as

ECM stiffeningGlaucomahydrogelmechanotransductionoutflow tractverteporfin

Identifiers

PMID37781615
PMCPMC10541092
OpenAlexW4386588398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.