Evidence map›Paper›PMID 37781579›Full record

ArticlebioRxiv : the preprint server for biology2023

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexes.

Caitlyn L McCafferty, Ophelia Papoulas, Chanjae Lee, Khanh Huy Bui, David W Taylor, Edward M Marcotte, John B Wallingford

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Caitlyn L McCaffertyDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0002-0872-4527
Ophelia PapoulasDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0002-6370-0616
Chanjae LeeDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0001-8748-1369
Khanh Huy BuiDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences McGill University, Québec, Canada.ORCID 0000-0003-2814-9889
David W TaylorDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0002-6198-1194
Edward M MarcotteDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0001-8808-180X
John B WallingfordDepartment of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.ORCID 0000-0001-8701-4293
The University of Texas at Austin · USMcGill University · CAUniversity of Basel · CH

Funding

Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
Proteomics and model organism humanization to decode human geneticsR35GM122480 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE · 2017 to 2026
$5.4M
Development and function in mucociliary epitheliaR01HL117164 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2013 to 2026
$4.7M
Imaging macromolecular machines in gene regulationR35GM138348 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI TAYLOR, DAVID W · 2020 to 2024
$1.9M
NHLBI NIH HHS R01 HL117164NICHD NIH HHS R01 HD085901NIGMS NIH HHS R35 GM122480NIGMS NIH HHS R35 GM138348
6 · The paper itself

Abstract

Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human diseases. Motile cilia contain myriad different proteins that assemble into an array of distinct machines, so understanding the interactions and functional hierarchies among them presents an important challenge. Here, we defined the protein interactome of motile axonemes using cross-linking mass spectrometry (XL/MS) in

Indexed as

ciliaciliopathycross-linking/mass spectrometrymulticiliated cellsprotein-protein interactionsproteomics

Identifiers

PMID37781579
PMCPMC10541116
OpenAlexW4383821461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.