Evidence map›Paper›PMID 37781403›Full record

ArticleFrontiers in immunology2023

Live imaging of microglia during sleeping sickness reveals early and heterogeneous inflammatory responses.

Nestor L Uzcategui, Sena Güçer, Cris Richter, Annika Speidel, Elizabeta Zirdum, Michael Duszenko, Olga Garaschuk, Katherine Figarella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nestor L UzcateguiDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Sena GüçerDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Cris RichterDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Annika SpeidelDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Elizabeta ZirdumDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Michael DuszenkoDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Olga GaraschukDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.
Katherine FigarellaDepartment of Neurophysiology, Institute of Physiology, University of Tuebingen, Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Invasion of the central nervous system (CNS) is the most serious consequence of Methods: To further address this issue, we implanted a cranial window on the cortex of B6.129P2(Cg)- Results and discussion: We uncovered an early involvement of microglia that precedes invasion of the CNS by the parasite. We accomplished a detailed characterization of the progressive sequence of events that correlates with microglial morphological changes and microgliosis. Our findings unveiled a heterogeneous microglial response in places of initial homeostatic disruption near brain barriers and pointed out an exceptional capability of microglia to hamper parasite proliferation inside the brain. We also found early signs of inflammation in the meninges, which synchronize with the microglial response. Moreover, we observed a massive infiltration of peripheral immune cells into the parenchyma as a signature in the final disease stage. Overall, our study provides new insights into the host-pathogen immune interactions in the meningeal and parenchymal compartments of the neocortex.

Indexed as

Trypanosoma brucei bruceiTrypanosomiasis, AfricanAnimalsBrainCentral Nervous SystemMiceMicrogliaheterogeneous responseimmune cell recruitmentinflammationmeningesmicrogliaTrypanosoma brucei

Identifiers

PMID37781403
PMCPMC10534015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.