Evidence map›Paper›PMID 37781371›Full record

ArticleFrontiers in immunology2023

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against

Nhu T Q Nguyen, Thien N M Doan, Kei Sato, Christine Tkaczyk, Bret R Sellman, Binh An Diep

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Development and validation of a rabbit model ofAntimicrobial agents and chemotherapy · 2026
    Article
  2. Review
  3. Article
  4. The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  5. DisarmingPathogens (Basel, Switzerland) · 2025
    Review
  6. Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nhu T Q NguyenDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Thien N M DoanDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Kei SatoDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Christine TkaczykEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Bret R SellmanEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Binh An DiepDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USAstraZeneca (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with septic shock caused by Methods: Anesthetized rabbits were ventilated with lung-protective low-tidal volume, instrumented for advanced hemodynamic monitoring, and characterized for longitudinal changes in acute myocardial dysfunction by echocardiography and sepsis-associated biomarkers after Results: Rabbits challenged with Conclusion: These results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting

Indexed as

ShockShock, SepticStaphylococcal InfectionsAnimalsAntibodies, MonoclonalHemolysin ProteinsHumansImmunoglobulin GLeukocidinsRabbitsRespiration, ArtificialStaphylococcus aureusStroke VolumeVentricular Function, LeftVitamin B 12Antibodies, Monoclonalfactor AHemolysin ProteinsImmunoglobulin GLeukocidinsVitamin B 12alpha-toxinclumping factor Ahyperdynamic septic shockleukocidinmechanical ventilated rabbit modelneutralizing monoclonal antibodiesPanton-Valentine leukocidinStaphylococcus aureus

Identifiers

PMID37781371
PMCPMC10541218
OpenAlexW4386836929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.