Evidence map›Paper›PMID 37781273›Full record

ArticleInternational journal of general medicine2023

Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia.

Kiros Weldegerima, Dawit Seyoum Gebremariam, Hansa Haftu, Gebretsadik Berhe, Amanuel Hadgu, Mohammed Mustefa Mohammedamin

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of general medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07401433 (Efficacy Of Levetiracetam in the Treatment of Neonatal Seizures Presenting at Tertiary Care Hospital.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07401433 nacompletednot on this mapstarted 2024, after this paper: background citation

Efficacy Of Levetiracetam in the Treatment of Neonatal Seizures Presenting at Tertiary Care Hospital.

TypeinterventionalSponsorHayat Abad Medical Complex, PeshawarRan2024 to 2025Enrolled260ConditionsNeonatal SeizuresArmsLevetiracetam, Phenobarbital Sodium Injection
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kiros WeldegerimaMekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia.
Dawit Seyoum GebremariamMekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia.ORCID 0000-0003-0564-9055
Hansa HaftuMekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia.ORCID 0000-0003-4413-3318
Gebretsadik BerheMekelle University, College of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle, Ethiopia.ORCID 0000-0002-5610-1383
Amanuel HadguMekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia.
Mohammed Mustefa MohammedaminMekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Seizure is the most frequently observed symptom of neurological disorders and an important determinant of outcome during neonatal period. In clinical practice, it is prevalent and observed in neonates admitted to hospital in low-resources countries, but due to the paucity of studies in these regions, little is known about its pattern, clinical outcomes of hospitalization, and its predictors. Therefore, aims to evaluate seizure patterns, clinical outcomes, and its predictors among neonates admitted to the NICU of ACSH, Mekelle, and Tigray. Methods: A hospital-based cross-sectional study design was conducted among neonates with neonatal seizures admitted to NICU of Ayder Comprehensive Specialized Hospital. Data collection was done from record reviews. SPSS Version 25 was used. Descriptive statistics and bivariate logistic regressions where a p-value of <0.05 is considered statistically significant. Results: Out of 1622 NICU admissions, 155 (9.6%) were cases of neonatal seizure. The most frequently observed types of seizure in this study were subtle 70 (45.1%) and tonic 49 (31.6%) respectively. At the end of hospitalization 70.3% of neonates were discharged improved, 21.3% of neonates died and 8.4% of neonates had severe neurologic deficits. Poorly controlled seizures (AOR 4.8, 95% CI 2.6-9.2), prolonged duration of labor (AOR 4.3, 95% CI 2.2-8.8) and seizure onset <72 hours (AOR 3.7, 95% CI 1.6-8.5), respectively, were found to be independent predictors of poor neonatal outcome. Conclusion: Of all neonatal admissions, neonatal seizure was observed in close to 9.6%. The most frequently observed type of seizure was subtle. Of those admitted neonates, 30% had poor outcomes following the end of their hospitalization or when they leave against medical advice for lack of improvement). Poorly controlled seizures, prolonged duration of labor, and seizure onset <72 hours were independent predictors of poor neonatal outcomes.

Indexed as

neonatal seizureoutcomepatternpredictors

Identifiers

PMID37781273
PMCPMC10540696

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Registered trials

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