ArticleThe journal of allergy and clinical immunology. Global2022
Long-term outcomes of oral immunotherapy for anaphylactic egg allergy in children.
Article in The journal of allergy and clinical immunology. Global, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Designing an Incremental Egg Oral Immunotherapy Protocol: A Strategic Approach with Safety as a Priority.Journal of asthma and allergy · 2026Article
- Recent Insights into the Epidemiology and Management of AnaphylaxisBalkan medical journal · 2025Review
- Ingestion of egg white after acquisition of oral tolerance with heated egg white in OVA-sensitized mice caused severe allergic symptoms.Bioscience of microbiota, food and health · 2025Article
- Oral immunotherapy with enteric-coated capsules for allergic rhinitis caused by house dust mites.Frontiers in allergy · 2024Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Studies of long-term oral immunotherapy (OIT) in children with anaphylactic egg allergy are limited. Objective: Our aim was to investigate the long-term outcomes of OIT for anaphylactic egg allergy. Methods: The participants included children (aged ≥ 5 years) with a history of anaphylaxis in response to eggs and objective reactions to oral food challenge (OFC) with 250 mg of egg protein. In the OIT group, the home starting dose of egg protein set during 5 days of hospitalization was ingested once daily and gradually increased to 1000 mg. Over the next year, participants temporarily discontinued OIT for 2 weeks and underwent OFC with 3100 mg of egg protein annually until they passed. The historical control group comprised patients who did not receive OIT and repeated OFCs annually. Results: In the OIT group (n = 20), the baseline median egg white- and ovomucoid-specific IgE levels were 45.5 and 38.5 kU Conclusion: Long-term OIT accelerated immunologic changes and enabled ingestion of 3100 mg of egg protein in half of the participants with anaphylactic egg allergy.
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