Evidence map›Paper›PMID 37781117›Full record

ReviewFrontiers in nutrition2023

Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical applications.

Jia Xiang, Ronald Mlambo, Ibrahim Shaw, Yimer Seid, Hamid Shah, Yongju He, Julius K S K Kpegah, Songwen Tan, Wenhu Zhou, Binsheng He

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  5. Heterojunction-Engineered g-CMolecules (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jia XiangAcademician Workstation, Changsha Medical University, Changsha, China.
Ronald MlamboXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Ibrahim ShawXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Yimer SeidXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Hamid ShahXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Yongju HeSchool of Materials Science and Engineering, Central South University, Changsha, Hunan, China.
Julius K S K KpegahDepartment of Plastic Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Songwen TanAcademician Workstation, Changsha Medical University, Changsha, China.
Wenhu ZhouAcademician Workstation, Changsha Medical University, Changsha, China.
Binsheng HeAcademician Workstation, Changsha Medical University, Changsha, China.
Central South University · CNChangsha Medical University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioflavonoids are natural polyphenolic secondary metabolites that are medicinal. These compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral, and anti-psoriasis properties to mention a few. Plant species that contain bioflavonoids should be preserved as such. Also, the bioactivity of the bioflavonoids as neutraceutical compounds is compromised following extraction due to their sensitivity to environmental factors like light, pH, and temperature. In other words, the bioflavonoids' shelf-life is affected. Scientists noticed that bioflavonoids have low solubility properties, poor absorption, and low bioavailability following consumption. Researchers came up with methods to encapsulate bioflavonoids in order to circumvent the challenges above and also to mask the unpleasant order these chemicals may have. Besides, scientists cryopreserve plant species that contain bioflavonoids. In this review, we discuss cryopreservation and bioflavonoid microencapsulation focusing mainly on vitrification, slow freezing, and freeze-drying microencapsulation techniques. In addition, we highlight bioflavonoid extraction techniques, medicinal properties, challenges, and future perspectives of cryopreservation and microencapsulation of bioflavonoids. Regardless of the uniqueness of cryopreservation and microencapsulation as methods to preserve bioflavonoid sources and bioflavonoids' bioactivity, there are challenges reported. Freeze-drying technology is costly. Cryoprotectants damage the integrity of plant cells, to say the least. Researchers are working very hard to overcome these challenges. Encapsulating bioflavonoids via coaxial electrospray and then cryopreserving the micro/nanocapsules produced can be very interesting.

Indexed as

anticancerantioxidantbioflavonoidscryopreservationmicroencapsulation

Identifiers

PMID37781117
PMCPMC10538722
OpenAlexW4386731804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.