Evidence map›Paper›PMID 37781111›Full record

ArticleFrontiers in nutrition2023

A randomized trial involving a multifunctional diet reveals systematic lipid remodeling and improvements in cardiometabolic risk factors in middle aged to aged adults.

Claudia Balderas Arroyo, Maider Greño Ocariz, Oksana Rogova, Mahmoud Al-Majdoub, Inger Björck, Juscelino Tovar, Peter Spégel

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02148653 (Efficacy of an Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Overweight Subjects), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02148653 nacompletednot on this map

Efficacy of an Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Overweight Subjects: Studies of Mechanisms Involving Metabolomics and Gut Microbiota Mapping

TypeinterventionalSponsorLund UniversityRan2014 to 2015Enrolled47ConditionsMetabolic Syndrome, Insulin Resistance, OverweightArmsMultifunctional diet (MFD), Control diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudia Balderas ArroyoCentre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden.
Maider Greño OcarizCentre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden.
Oksana RogovaCentre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden.
Mahmoud Al-MajdoubUnit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Inger BjörckRetired, Lund, Sweden.
Juscelino TovarDepartment of Food Technology, Engineering and Nutrition, Food for Health Science Centre Lund University, Lund, Sweden.
Peter SpégelCentre for Analysis and Synthesis, Department of Chemistry, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A multifunctional diet (MFD) combining foods and ingredients with proven functional properties, such as fatty fish and fiber-rich foods, among others, was developed and shown to markedly reduce cardiometabolic risk-associated factors. Objective: Here, we aim at examining metabolic physiological changes associated with these improvements. Methods: Adult overweight individuals without other risk factors were enrolled in an 8-week randomized controlled intervention following a parallel design, with one group ( Results: Weight loss was similar between groups. The MFD and CD resulted in altered levels of 137 and 78 metabolites, respectively. Out of these, 83 were uniquely altered by the MFD and only 24 by the CD. The MFD-elicited alterations in lipid levels depended on carbon number and degree of unsaturation. Conclusion: An MFD elicits weight loss-independent systematic lipid remodeling, promoting increased circulating levels of long and highly unsaturated lipids. Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT02148653?term=NCT02148653&draw=2&rank=1, NCT02148653.

Indexed as

carbon numbercardiovascular diseasedegree of unsaturationdiabetesfunctional foodsmetabolic syndrome

Identifiers

PMID37781111
PMCPMC10538628

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.