Evidence map›Paper›PMID 37781088›Full record

ArticleNeuro-oncology advances

The sex-dependent impact of PER2 polymorphism on sleep and activity in a novel mouse model of cranial-irradiation-induced hypersomnolence.

Kendra A Adegbesan, Francesco Tomassoni Ardori, Sudhirkumar Yanpallewar, Sean P Bradley, Yogita Chudasama, Elizabeth Vera, Nicole Briceno, Amanda L King, Lino Tessarollo, Mark R Gilbert and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kendra A AdegbesanNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Francesco Tomassoni ArdoriNeural Development Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sudhirkumar YanpallewarNeural Development Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sean P BradleyRodent Behavior Core, National Institute of Mental Health, National Institutes of Health, Frederick, MD, USA.
Yogita ChudasamaRodent Behavior Core, National Institute of Mental Health, National Institutes of Health, Frederick, MD, USA.
Elizabeth VeraNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Nicole BricenoNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amanda L KingNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-8448-6914
Lino TessarolloNeural Development Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark R GilbertNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Vivian A GuedesNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
DeeDee K SmartRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-3471-0871
Terri S ArmstrongNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Dorela D Shuboni-MulliganNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-7575-8666
National Institutes of Health · US

Funding

Rodent Behavioral Core: The Analysis of BehaviorZICMH002952 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI CHUDASAMA, YOGITA · 2016 to 2025
$7.5M
Intramural NIH HHS ZIC MH002952
6 · The paper itself

Abstract

Background: Hypersomnolence is a common and disruptive side effect of cranial radiotherapy and is associated with fatigue and disturbances in mood and cognition in primary brain tumor (PBT) patients. The biological underpinnings of this effect are not understood. Our laboratory has previously found that the presence of a single nucleotide polymorphism (rs934945, G-E mutation) in the PERIOD2 (PER2) clock gene was associated with a decreased likelihood of fatigue in PBT patients. Here, we aim to understand the effects of PER2 polymorphism on radiation susceptibility within a murine model of cranial-irradiation-induced hypersomnolence (C-RIH). Methods: Male and female transgenic mice were generated using CRISPR-Cas9, replacing the endogenous mouse PER2:CRY1 binding domain with its human isoform with (h Results: During their active phase, h Conclusions: The PER2 rs934945 polymorphism had long-lasting behavioral effects associated with radiation toxicity, particularly in sleep in females and the activity of all animals. Our findings shed light on biological mechanisms underlying C-RIH.

Indexed as

circadian gene polymorphismscognitionprimary brain tumorsradiation toxicitysex differencessleep

Identifiers

PMID37781088
PMCPMC10540885
OpenAlexW4386408351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.