ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex-specific immune-brain coupling in hippocampal circuits and Alzheimer's disease vulnerability.Research square · 2026Article
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.bioRxiv : the preprint server for biology · 2026Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.bioRxiv : the preprint server for biology · 2026Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Modeling a Shared Reality of Tractography through Varied Structural Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Is correction for gradient nonlinearity necessary in a brain diffusion tensor MRI clinical study?PloS one · 2026Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Harmonized connectome resampling for variance in voxel sizes.Magnetic resonance imaging · 2025Article
- Longitudinal Changes in Brain Diffusion Characteristics Associated With Cognition and Vascular Risk Factors: The ARIC-NCS Study.Neurology · 2025Article
- White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.JAMA neurology · 2025Article
- In vivo submillimeter diffusion MRI dataset of 9 macaque brains curated for tractography.Scientific data · 2025Article
- White matter fractional anisotropy decreases precede hyperintensities in Alzheimer's disease.Cell reports. Medicine · 2025Article
- The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mapping the aging brain: Insights into microstructural changes from free water-corrected fractional anisotropy.Neuroscience letters · 2025Article
- Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Sex, racial, andbioRxiv : the preprint server for biology · 2024Article
- Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Abstract
Introduction: It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. Methods: Diffusion MRI data from several well-established longitudinal cohorts of aging (Alzheimer's Disease Neuroimaging Initiative [ADNI], Baltimore Longitudinal Study of Aging [BLSA], Vanderbilt Memory & Aging Project [VMAP]) were free-water corrected and harmonized. This dataset included 1723 participants (age at baseline: 72.8 ± 8.87 years, 49.5% male) and 4605 imaging sessions (follow-up time: 2.97 ± 2.09 years, follow-up range: 1-13 years, mean number of visits: 4.42 ± 1.98). Differences in white matter microstructural decline in normal and abnormal agers was assessed. Results: While we found a global decline in white matter in normal/abnormal aging, we found that several white matter tracts (e.g., cingulum bundle) were vulnerable to abnormal aging. Conclusions: There is a prevalent role of white matter microstructural decline in aging, and future large-scale studies in this area may further refine our understanding of the underlying neurodegenerative processes. HIGHLIGHTS: Longitudinal data were free-water corrected and harmonized.Global effects of white matter decline were seen in normal and abnormal aging.The free-water metric was most vulnerable to abnormal aging.Cingulum free-water was the most vulnerable to abnormal aging.
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