Evidence map›Paper›PMID 37780758›Full record

ArticleHeliyon2023

RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities.

Lei Wu, Fang Wang, Carole L Moncman, Mritunjay Pandey, Harrison A Clarke, Hilaree N Frazier, Lyndsay E A Young, Matthew S Gentry, Weikang Cai, Olivier Thibault and 2 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lei WuDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Fang WangDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Carole L MoncmanDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Mritunjay PandeyDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Harrison A ClarkeDepartment of Neuroscience, College of Medicine, University of Kentucky, KY 40536, USA.
Hilaree N FrazierDepartment of Pharmacological and Nutritional Sciences, College of Medicine, University of Kentucky, KY 40536, USA.
Lyndsay E A YoungDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Matthew S GentryDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
Weikang CaiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, NY 11568, USA.
Olivier ThibaultDepartment of Pharmacological and Nutritional Sciences, College of Medicine, University of Kentucky, KY 40536, USA.
Ramon C SunDepartment of Neuroscience, College of Medicine, University of Kentucky, KY 40536, USA.
Douglas A AndresDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, KY 40536, USA.
University of Kentucky · USNew York Institute of Technology · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
Brain Glycogen-Metabolism,Mechanisms, and Therapeutic PotentialR35NS116824 · NINDS · UNIVERSITY OF KENTUCKY · PI Matthew S. Gentry · 2020 to 2026
$8.2M
Metabolic syndrome and hippocampal Ca2+ dysregulation in aging-related memory decR01AG033649 · NIA · UNIVERSITY OF KENTUCKY · PI THIBAULT, OLIVIER · 2009 to 2019
$3.4M
Regulation of Neuronal Survival by the Rit GTPaseR01NS045103 · NINDS · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN · 2003 to 2012
$2.7M
RIT1-mediated Protection following Traumatic Brain InjuryR01NS102196 · NINDS · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN · 2018 to 2022
$2.5M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG057461 · NIA · UNIVERSITY OF KENTUCKY · PI MURPHY, MICHAEL PAUL, VAN ELDIK, LINDA J · 2017 to 2021
$2.1M
Astrocyte-derived signals for neuronal and behavioral modulation and its implications in mental illness.R01MH125903 · NIMH · UNIVERSITY OF KENTUCKY · PI CAI, WEIKANG · 2021 to 2025
$1.6M
G Protein Signaling in Brain InjuryR56NS124707 · NINDS · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN · 2022 to 2022
$536k
NCI NIH HHS P30 CA177558NIA NIH HHS R01 AG033649NIA NIH HHS T32 AG057461NIMH NIH HHS R01 MH125903NINDS NIH HHS P01 NS097197NINDS NIH HHS R01 NS045103NINDS NIH HHS R01 NS102196NINDS NIH HHS R35 NS116824NINDS NIH HHS R56 NS124707
6 · The paper itself

Abstract

Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a

Indexed as

Endothelin-1LipidomicsMALDI-MSIMyelinMyelinationOligodendrocyte progenitor cellRasRit GTPase

Identifiers

PMID37780758
PMCPMC10539968
OpenAlexW4386986370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.