ArticleFrontiers in neurology2023
Predictors of failure of early neurological improvement in early time window following endovascular thrombectomy: a multi-center study.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Decompressive craniectomy after endovascular thrombectomy in acute ischemic stroke: a systematic review.Acta neurochirurgica · 2025Pooled it
- Development of a simple clinical score to predict early neurological improvement after mechanical thrombectomy: a single-centre cohort study.BMC neurology · 2026Article
- Association between fetal-type posterior cerebral artery variants and NIHSS-defined stroke severity in acute posterior circulation infarction.Frontiers in neurology · 2026Article
- The Impact of Meticulous Nursing on Self-Care Ability Within Two Weeks Postoperatively in Patients with Acute Stroke.Journal of multidisciplinary healthcare · 2026Article
- Efficacy evaluation of the hard-channel technique and transsylvian microsurgical operation in the treatment of basal ganglia haemorrhage.Annals of medicine · 2025Article
- Identifying the predictors of ultra early neurological improvement and its role in functional outcome after endovascular thrombectomy in acute ischemic stroke.Frontiers in neurology · 2025Article
- Predictive outcome of late window ischemic stroke patients following endovascular therapy: a multi-center study.Frontiers in neurology · 2025Article
- Endovascular Treatment in Stroke Patients of Working Age: A Multicenter Observational Study of Real-World Outcomes.Therapeutics and clinical risk management · 2025Article
- A machine learning-based predictive nomogram for early neurological improvement after thrombolysis in acute ischemic stroke.Frontiers in neurology · 2025Article
- Can ischemic stroke patients with mTICI of 2b achieve similar outcomes compared to those with complete recanalization following endovascular therapy?Frontiers in neurology · 2024Article
- Predicting functional outcome in acute ischemic stroke patients after endovascular treatment by machine learning.Translational neuroscience · 2023Article
- Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a multi-center study.Frontiers in neuroscience · 2023Article
- Post-ASPECTS and Post-PC-ASPECTS Predict the Outcome of Anterior and Posterior Ischemic Stroke Following Thrombectomy.Risk management and healthcare policy · 2023Article
- Unmet Needs in Acute Ischemic Stroke: Overcoming Recalcitrant Clots.Cardiology in reviewReview
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Authors and funding
17 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: Endovascular thrombectomy (EVT) has become the gold standard in the treatment of acute stroke patients. However, not all patients respond well to this treatment despite successful attempts. In this study, we aimed to identify variables associated with the failure of improvements following EVT. Methods: We retrospectively analyzed prospectively collected data of 292 ischemic stroke patients with large vessel occlusion who underwent EVT at three academic stroke centers in China from January 2019 to February 2022. All patients were above 18 years old and had symptoms onset ≤6 h. A decrease of more than 4 points on the National Institute of Health Stroke Scale (NIHSS) after 24 h compared with admission or an NIHSS of 0 or 1 after 24 h was defined as early neurological improvement (ENI), whereas a lack of such improvement in the NIHSS was defined as a failure of early neurological improvement (FENI). A favorable outcome was defined as a modified Rankin scale (mRS) score of 0-2 after 90 days. Results: A total of 183 patients were included in the final analyses, 126 of whom had FENI, while 57 had ENI. Favorable outcomes occurred in 80.7% of patients in the ENI group, in contrast to only 22.2% in the FENI group ( Conclusion: Diabetes mellitus history, pre-stroke mRS, longer last known well-to-puncture time, lack of modified thrombolysis in cerebral infarction = 3, and the number of mechanical thrombectomy passes are the predictors of FENI. Future large-scale studies are required to validate these findings.
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