ArticleFrontiers in medicine2023
Specialized active leprosy search strategies in an endemic area of the Brazilian Amazon identifies a hypermutated
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- RIMOXCLAMIN's Therapeutic Impact in a Larger Brazilian Hansen's Disease Population.Open forum infectious diseases · 2026Trial
- Serum geoepidemiology of leprosy biomarkers in a city-wide COVID-19 survey in Brazil.BMC infectious diseases · 2026Article
- Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil.Medical microbiology and immunology · 2025Article
- Molecular Detection ofTropical medicine and infectious disease · 2025Review
- Efficiency of the Sensory Mapping Score for Hansens's disease diagnosis and follow-up: a functional cure criterion?Frontiers in medicine · 2025Article
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Authors and funding
15 authors at 6 institutions in 3 countries.
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Abstract
Introduction: Leprosy, an infectious disease caused by Methods: During an active surveillance of one week, we enrolled 318 individuals using three different strategies to enroll subjects for this study: (i) an active survey of previously treated cases from 2006 to 2016 found in the Brazil National Notifiable Disease Information System database ( Results: Anti-PGL-I positivity was highest in the new leprosy case group (52%) followed by the treated group (40.9%), HHC (40%) and lowest in SC (24.6%). RLEP qPCR from SSS was performed on 124 individuals, 22 in treated cases, 24 in newly diagnosed leprosy cases, and 78 in HHC. We detected 29.0% (36/124) positivity overall in this sample set. The positivity in treated cases was 31.8% (7/22), while in newly diagnosed leprosy cases the number of positives were higher, 45.8% (11/23) and lower in HHC at 23.7% (18/76). Whole genome sequencing of Discussion: This study represents the extent of leprosy in an active surveillance campaign during a single week in the city of Castanhal, a city that we have previously surveyed several times during the past ten years. Our results indicate the continuing high transmission of leprosy that includes fairly high rates of new cases detected in children indicating recent spread by multiple foci of infection in the community. An unusual case of a hypermutated
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