Evidence map›Paper›PMID 37780496›Full record

ArticleFrontiers in plant science2023

Cytoplasmic male sterility and abortive seed traits generated through mitochondrial genome editing coupled with allotopic expression of

Ralph E Dewey, Devarshi Selote, H Carol Griffin, Allison N Dickey, Derek Jantz, J Jeff Smith, Anna Matthiadis, Josh Strable, Caitlin Kestell, William A Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ralph E DeweyDepartment of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, United States.
Devarshi SeloteDepartment of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, United States.
H Carol GriffinDepartment of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, United States.
Allison N DickeyBioinformatics Research Center, North Carolina State University, Raleigh, NC, United States.
Derek JantzPrecision BioSciences, Durham, NC, United States.
J Jeff SmithPrecision BioSciences, Durham, NC, United States.
Anna MatthiadisElo Life Systems, Durham, NC, United States.
Josh StrableDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, United States.
Caitlin KestellDepartment of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, United States.
William A SmithDepartment of Crop and Soil Sciences, North Carolina State University, Raleigh, NC, United States.
North Carolina State University · USPrecision BioSciences (United States) · USLife Systems (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allotopic expression is the term given for the deliberate relocation of gene function from an organellar genome to the nuclear genome. We hypothesized that the allotopic expression of an essential mitochondrial gene using a promoter that expressed efficiently in all cell types except those responsible for male reproduction would yield a cytoplasmic male sterility (CMS) phenotype once the endogenous mitochondrial gene was inactivated via genome editing. To test this, we repurposed the mitochondrially encoded

Indexed as

allotopic expressionatp1custom-designed meganucleaseshybrid seed systemsmitoarcusstenospermocarpysubstoichiometric shiftingtransgene containment

Identifiers

PMID37780496
PMCPMC10541219
OpenAlexW4386836572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.