Evidence map›Paper›PMID 37779857›Full record

ArticleClinical kidney journal2023

High exposure to tacrolimus is associated with spontaneous remission of recurrent membranous nephropathy after kidney transplantation.

Anna Buxeda, Fernando Caravaca-Fontán, Luis Alberto Vigara, José Luis Pérez-Canga, Emma Calatayud, Ana Coloma, Auxiliadora Mazuecos, Emilio Rodrigo, Asunción Sancho, Edoardo Melilli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Post-Transplant Glomerulonephritis: Challenges and Solutions.International journal of nephrology and renovascular disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Anna BuxedaDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Fernando Caravaca-FontánInstituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID https://orcid.org/0000-0002-5830-9663
Luis Alberto VigaraDepartment of Nephrology, Hospital Universitario Puerta del Mar, Cádiz, Spain.ORCID https://orcid.org/0000-0001-6568-6160
José Luis Pérez-CangaDepartment of Nephrology, Hospital Universitario Marqués de Valdecilla / IDIVAL, Santander, Spain.ORCID https://orcid.org/0000-0001-6753-1146
Emma CalatayudDepartment of Nephrology, Hospital Universitari Doctor Peset, Valencia, Spain.
Ana ColomaDepartment of Nephrology, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
Auxiliadora MazuecosDepartment of Nephrology, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Emilio RodrigoDepartment of Nephrology, Hospital Universitario Marqués de Valdecilla / IDIVAL, Santander, Spain.
Asunción SanchoDepartment of Nephrology, Hospital Universitari Doctor Peset, Valencia, Spain.ORCID https://orcid.org/0000-0002-4170-9003
Edoardo MelilliDepartment of Nephrology, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
Manuel PragaInstituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain.
María José Pérez-SáezDepartment of Nephrology, Hospital del Mar, Barcelona, Spain.
Julio PascualHospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.ORCID https://orcid.org/0000-0002-4735-7838
Bellvitge University Hospital · ESHospital Del Mar · ESHospital Universitario Doctor Peset · ESHospital Universitario Puerta del Mar · ESInstituto de Investigación Marqués de Valdecilla · ESResearch Institute Hospital 12 de Octubre · ESHospital Universitario 12 De Octubre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We aimed to characterize the incidence and clinical presentation of membranous nephropathy (MN) after kidney transplantation (KT), and to assess allograft outcomes according to proteinuria rates and immunosuppression management. Methods: Multicenter retrospective cohort study including patients from six Spanish centers who received a KT between 1991-2019. Demographic, clinical, and histological data were collected from recipients with biopsy-proven MN as primary kidney disease ( Results: Up to 25.4% of patients with biopsy-proven MN as primary kidney disease recurred after a median time of 18.1 months posttransplant, without a clear impact on graft survival. Proteinuria at 3-months post-KT was a predictor for MN recurrence (rMN, HR 4.28; Conclusions: One-fourth of patients with biopsy-proven MN as primary kidney disease recurred after KT, without a clear impact on graft survival. Spontaneous remission after rMN was associated with a higher exposure to tacrolimus before recurrence.

Indexed as

kidney transplantationmembranous nephropathyproteinuriarecurrencetacrolimus

Identifiers

PMID37779857
PMCPMC10539211
OpenAlexW4365136943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.