ArticleClinical kidney journal2023
Critically ill patients with acute kidney injury: clinical determinants and post-mortem histology.
Article in Clinical kidney journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Pathophysiology and Management of Sepsis-associated Acute Kidney Injury.Clinics in chest medicine · 2026Review
- Prediction of hospital mortality in sepsis-associated acute kidney injury using a machine-learning approach: a multicenter study using SHAP interpretability analysis.Clinical kidney journal · 2026Article
- Hyperlactatemia in critically ill patients with acute kidney injury treated with renal replacement therapy in the intensive care unit.BMC nephrology · 2025Observational
- The utility of point-of-care ultrasound in critical care nephrology.Frontiers in nephrology · 2024Review
- Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach.Intensive care medicine experimental · 2023Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) portends a poor prognosis. We aimed to better characterize predictors of survival and the mechanism of kidney failure in these patients. Methods: This was a retrospective observational study using clinical and radiological electronic health records, analysed by univariable and multivariable binary logistic regression. Histopathological examination of post-mortem renal tissue was performed. Results: Among 157 patients with AKI requiring RRT, higher serum creatinine at RRT initiation associated with increased ICU survival [odds ratio (OR) 0.33, 95% confidence interval (CI) 0.17-0.62, Conclusions: Confounding of creatinine by muscle mass undermines its use as a marker of AKI severity in clinical studies. Volume management and urine output are key determinants of outcome. Loss of synaptopodin implicates glomerular injury in the pathogenesis of S-AKI.
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Registered trials
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