Evidence map›Paper›PMID 37779094›Full record

ArticleThe Journal of reproduction and development2023

FABP4 mediates endoplasmic reticulum stress and autophagy to regulate endometrial epithelial cell function during early sheep gestation.

Meijun Song, Kexing Hao, Fenghua Qi, Wenjuan Zhao, Zhengrong Wang, Jing Wang, Guangdong Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meijun SongCollege of Animal Science and Technology, Shihezi University, Xinjiang 832000, China.
Kexing HaoCollege of Animal Science and Technology, Shihezi University, Xinjiang 832000, China.
Fenghua QiCollege of Animal Science and Technology, Shihezi University, Xinjiang 832000, China.
Wenjuan ZhaoXinjiang Academy of Agriculture and Reclamation Sciences, Xinjiang 832000, China.
Zhengrong WangXinjiang Academy of Agriculture and Reclamation Sciences, Xinjiang 832000, China.
Jing WangCollege of Animal Science and Technology, Shihezi University, Xinjiang 832000, China.
Guangdong HuCollege of Animal Science and Technology, Shihezi University, Xinjiang 832000, China.
Shihezi University · CNXinjiang Academy of Agricultural and Reclamation Science · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic changes in the endometrium are crucial for establishing early pregnancy in ruminants. Blastocyst elongation and implantation require hormones and nutrients to be secreted from the maternal endometrium. The fatty acid-binding protein FABP4 is a widely expressed fatty acid transport protein that promotes cell proliferation, migration, and invasion and is involved in conceptus implantation. However, the mechanism underlying the functional regulation of endometrial epithelial cells (EECs) by FABP4 during ovine peri-implantation remains unclear. We simulated hormonal changes in vitro in sheep EECs (SEECs) during the peri-implantation period and found that it elevated FABP4 expression. FABP4 inhibition significantly reduced cell migration, endoplasmic reticulum stress, and autophagy, suggesting that FABP4 regulates endometrial function in sheep. Moreover, the FABP4 inhibitor BMS309403 counteracted hormone-mediated functional changes in SEECs, and an endoplasmic reticulum stress activator and autophagy inhibitor reversed the abnormal secretion of prostaglandins induced by FABP4 inhibition. These results suggest that FABP4 affects ovine endometrial function during early gestation by regulating endoplasmic reticulum stress and autophagy in SEECs.

Indexed as

EndometriumEndoplasmic Reticulum StressFatty Acid-Binding ProteinsAnimalsAutophagyEpithelial CellsFemaleHormonesPregnancySheepFatty Acid-Binding ProteinsHormonesAutophagyEndometrial epithelial cellsEndoplasmic reticulum stressFatty acid-binding proteinImplantation

Identifiers

PMID37779094
PMCPMC10721855
OpenAlexW4387237716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.