Evidence map›Paper›PMID 37778920›Full record

ReviewCytokine & growth factor reviews2023

The odyssey of cGAS: From cytosol to nucleus.

Wenzhuo Hao, Wenjun Li, Lingyan Wang, Shitao Li

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytokine & growth factor reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wenzhuo HaoDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA.
Wenjun LiDepartment of Craniofacial Biomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lingyan WangDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA. Electronic address: lwang32@tulane.edu.
Shitao LiDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA. Electronic address: sli38@tulane.edu.
Tulane University · USUniversity of North Carolina at Chapel Hill · US

Funding

Role of FIP200 in RIG-I-mediated innate immunityR01AI141399 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LI, SHITAO · 2019 to 2023
$1.7M
Phosphorylation mimetic motif of cryptochrome proteins blocks IRF3 activationR21AI168449 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LI, SHITAO · 2023 to 2024
$420k
K63-linked ubiquitination regulates cGAS activation upon DNA damageR21AI166043 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LI, SHITAO · 2021 to 2022
$418k
NIAID NIH HHS R01 AI141399NIAID NIH HHS R21 AI166043NIAID NIH HHS R21 AI168449
6 · The paper itself

Abstract

The cyclic GMP-AMP synthase (cGAS) is a widely recognized pattern recognition receptor responsible for detecting pathogenic DNA in the cytosol and inducing the production of type I interferon (IFN) to combat infections. The recently discovered nuclear localization of cGAS has changed the old dogma, illuminated a captivating dimension of innate immunity, and sparked many fundamental questions beyond the field of immunology. This review explores cGAS nuclear localization models, activation mechanisms, and biological significance. This expansion challenges the conventional understanding of cGAS and opens new avenues for scientific exploration, promising insights into cellular surveillance and potentially unveiling new therapeutic targets for immune disorders.

Indexed as

DNAInterferon Type ICytosolHumansImmunity, InnateNucleotidyltransferasesDNAInterferon Type INucleotidyltransferasesChromatin tetheringInterferonNuclear cGASNucleosome

Identifiers

PMID37778920
PMCPMC11542052
OpenAlexW4387095669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.