Evidence map›Paper›PMID 37778627›Full record

ReviewThe journal of allergy and clinical immunology. In practice2024

Should Biologics Be Used Before Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease?

Tanya M Laidlaw, Andrew A White

Open access · greenAbstract readReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Using Biologics in the Prevention of Anaphylaxis.Current allergy and asthma reports · 2025
    Review
  3. Efficacy of Biologics in NSAID-ERD: United Airways From the Nose to the Bronchi.The journal of allergy and clinical immunology. In practice · 2024
    Review
  4. The Diagnosis and Treatment of Chronic Rhinosinusitis.Deutsches Arzteblatt international · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tanya M LaidlawDivision of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: tlaidlaw@partners.org.
Andrew A WhiteDivision of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, Calif.
Brigham and Women's Hospital · USScripps Clinic · US

Funding

Therapeutic Control of Aspirin-Exacerbated Respiratory DiseaseU19AI095219 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Maria Gutierrez-Arcelus · 2011 to 2026
$29.1M
IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2M
NIAID NIH HHS T32 AI007306NIAID NIH HHS U19 AI095219
6 · The paper itself

Abstract

There has been a paradigm shift in the management of aspirin-exacerbated respiratory disease (AERD). It started in 2015 when the first biologic was Food and Drug Administration (FDA) approved for severe eosinophilic asthma. Thus, there emerged a new era in the treatment of patients with type 2-mediated airway diseases. This has led to an increasing number of options for patients, undoubtably a great thing, but has left clinicians without a clear answer for how to balance the therapies that exist for AERD, what to recommend for treatment, and how to best assess the benefits and risks of each therapy. This paper aims to explore these benefits and risks, and to provide a roadmap for future studies.

Indexed as

AsthmaAsthma, Aspirin-InducedBiological ProductsNasal PolypsRespiration DisordersRhinitisSinusitisAspirinChronic DiseaseDesensitization, ImmunologicHumansAspirinBiological ProductsAERDAspirin desensitizationAspirin-exacerbated respiratory diseaseBenralizumabChronic rhinosinusitisCRSwNPDupilumabMepolizumabNasal polypsOmalizumab

Identifiers

PMID37778627
PMCPMC10842409
OpenAlexW4387166183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.