Evidence map›Paper›PMID 37778281›Full record

ArticlePregnancy hypertension2023

Increased adherence to ACOG diagnostic guidelines for HDP following a workshop in Bolivia, a LMIC.

Lilian Toledo-Jaldin, Litzi Lazo-Vega, Laura Grau, Ian Lawrence, Alison Larrea-Alvarado, Rodrigo Mizutani, Sebastian Rocabado, Vikram Vasan, Mary Sammel, Colleen G Julian and 1 more

Abstract read
In one paragraph

Article in Pregnancy hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The uteroplacental circulation at high altitude: adaptation and maladaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  3. Surviving birth at high altitude.The Journal of physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lilian Toledo-JaldinHospital Materno-Infantil, Caja Nacional de Salud, La Paz, Bolivia.
Litzi Lazo-VegaHospital Materno-Infantil, Caja Nacional de Salud, La Paz, Bolivia.
Laura GrauDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, United States.
Ian LawrenceUniversity of Colorado Denver School of Medicine, Aurora, CO 80045, United States.
Alison Larrea-AlvaradoHospital Materno-Infantil, Caja Nacional de Salud, La Paz, Bolivia.
Rodrigo MizutaniUniversidad Nuestra Señora de La Paz, Escuela de Medicina, La Paz, Bolivia.
Sebastian RocabadoUniversidad Nuestra Señora de La Paz, Escuela de Medicina, La Paz, Bolivia.
Vikram VasanKrieger School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD, United States.
Mary SammelDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, United States; Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, CO 80045, United States.
Colleen G JulianDepartment of Medicine, University of Colorado Denver, Aurora, CO 80045, United States.
Lorna G MooreDepartment of Obstetrics and Gynecology, University of Colorado Denver, Aurora, CO 80045, United States. Electronic address: Lorna.Moore@cuanschutz.edu.

Funding

Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growthR01HD088590 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Colleen Glyde Julian, LORNA G. MOORE · 2016 to 2026
$4.3M
Epigenetic and Fetal Origins of Hypoxia-Induced Pulmonary HypertensionR01HL138181 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE · 2018 to 2021
$1.6M
Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in BoliviaR21TW010797 · FIC · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE, MOORE, LORNA G. · 2017 to 2018
$389k
FIC NIH HHS R21 TW010797NHLBI NIH HHS R01 HL138181NICHD NIH HHS R01 HD088590
6 · The paper itself

Abstract

objectivesHypertensive disorders of pregnancy (HDP) exert a heavy mortality burden in low- to middle-income countries (LMIC). ACOG revised HDP diagnostic guidelines to improve identifying pregnancies at greatest risk but whether they are used in LMIC is unknown. STUDY

designWe held a workshop to review ACOG guidelines in La Paz, Bolivia (BO) and then reviewed prenatal, labor and delivery records for all HDP diagnoses and twice as many controls at its three largest delivery sites during the year before and the nine months after a workshop (n = 1376 cases, 2851 controls during the two periods).

main outcome measuresHDP diagnoses, maternal, and infant characteristics.

resultsBolivian and ACOG criteria identified similar frequencies of gestational hypertension (GH) or eclampsia, but preeclampsia with severe features (sPE) was under- and preeclampsia without severe features (PE) over-reported during both periods. Increases occurred after the workshop in testing for proteinuria and the detection of abnormal laboratory values and severe hypertension in HDP women. Any adverse maternal outcome occurred more frequently after the workshop in women with BO PE or sPE diagnoses who met ACOG sPE criteria.

conclusionsUtilization of ACOG guidelines increased following the workshop and improved identification of PE or sPE pregnancies with adverse maternal outcomes. Continued use of a CLAP perinatal form recognizing HELLP as the only kind of sPE resulted in under-reporting of sPE.

fundingNIH TW010797, HD088590, HL138181.

Indexed as

HELLP SyndromeHypertension, Pregnancy-InducedPre-EclampsiaBoliviaDeveloping CountriesFemaleHumansPregnancyHypertensionHypoxiaMaternal mortalityPerinatal mortalityPreeclampsiaPregnancy

Identifiers

PMID37778281
PMCPMC10841895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.