Evidence map›Paper›PMID 37777963›Full record

ArticleCell reports2023

TET3 plays a critical role in white adipose development and diet-induced remodeling.

Byung Chul Jung, Dongjoo You, Ikjun Lee, Daofeng Li, Rebecca L Schill, Katherine Ma, Anna Pi, Zehan Song, Wei-Chieh Mu, Ting Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Regulators of RNA mFrontiers in endocrinology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Byung Chul JungNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Dongjoo YouNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Ikjun LeeNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Daofeng LiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Rebecca L SchillDepartment of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA.
Katherine MaNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Anna PiNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Zehan SongNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Wei-Chieh MuNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MO, USA.
Alexander S BanksDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Sona KangNutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA. Electronic address: kangs@berkeley.edu.
University of California, Berkeley · USUniversity of Michigan · USWashington University in St. Louis · USBeth Israel Deaconess Medical Center · US

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Epigenetic regulation of adipose development and remodelingR01DK116008 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Sona Kang · 2018 to 2026
$3.6M
Training Program in Metabolic BiologyT32DK128783 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andreas Stahl · 2022 to 2026
$776k
Therapeutic targeting of miR-128-1 in Duchenne muscular dystrophyR56NS128721 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KANG, SONA, NAAR, ANDERS M · 2022 to 2022
$401k
NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK116008NIDDK NIH HHS T32 DK128783NINDS NIH HHS R56 NS128721
6 · The paper itself

Abstract

Maintaining healthy adipose tissue is crucial for metabolic health, requiring a deeper understanding of adipocyte development and response to high-calorie diets. This study highlights the importance of TET3 during white adipose tissue (WAT) development and expansion. Selective depletion of Tet3 in adipose precursor cells (APCs) reduces adipogenesis, protects against diet-induced adipose expansion, and enhances whole-body metabolism. Transcriptomic analysis of wild-type and Tet3 knockout (KO) APCs unveiled TET3 target genes, including Pparg and several genes linked to the extracellular matrix, pivotal for adipogenesis and remodeling. DNA methylation profiling and functional studies underscore the importance of DNA demethylation in gene regulation. Remarkably, targeted DNA demethylation at the Pparg promoter restored its transcription. In conclusion, TET3 significantly governs adipogenesis and diet-induced adipose expansion by regulating key target genes in APCs.

Indexed as

Adipose TissueDioxygenasesAdipocytesAdipogenesisAdipose Tissue, WhiteAnimalsCell DifferentiationDietHumansMiceObesityPPAR gammaDioxygenasesPPAR gammaTET3 protein, humanTet3 protein, mouseadipocyte expansionadipocyte precursor cellsadipocytesadipogenesisCP: MetabolismCP: Molecular biologyDNA demethylationepigeneticsTET3

Identifiers

PMID37777963
PMCPMC10763978
OpenAlexW4387216018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.