ArticleCritical care (London, England)2023
Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study.
Article in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07038291 (Factors Associated With Extubation Failure in Kanigara ICU), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo
Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of controlled hypotension on postoperative awakening quality in shoulder arthroscopy with lateral decubitus rotator cuff repair.BMC anesthesiology · 2025Trial
- Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial.Intensive care medicine · 2024Trial
- Airway Anatomy as a Predictor of Tracheostomy in Critically Ill Patients: A Multicampus Analysis of Airway Grade, Admission Diagnosis, and Clinical Trajectory.Laryngoscope investigative otolaryngology · 2026Article
- Reintubation in the ICU: A Prospective Observational Study of Its Impact on Recovery Outcomes and Mortality.Cureus · 2026Article
- The ABCDEFG point-of-care ultrasound protocol for acute non-traumatic abdominal pain: a prospective observational study.Journal of ultrasound · 2026Observational
- Interpreting reductions in reintubation after extubation: clinical implications and future directions.Intensive care medicine · 2026Article
- Association of extubation failure rate with patient outcomes.Acute and critical care · 2026Article
- Diagnostic accuracy of tests for assessing readiness for liberation from mechanical ventilation in adults: an overview of reviews.Journal of intensive care · 2026Review
- Ventilator-induced lung injury: from mechanisms to integrated clinical management.Frontiers in medicine · 2026Review
- Construction and validation of a machine learning-based prediction model for 48-hour reintubation risk in mechanically ventilated patients.Frontiers in medicine · 2026Article
- Predictors of ventilator-associated pneumonia in intubated pediatric trauma patients.Pediatric surgery international · 2025Article
- Impact of pressure support ventilation duration after a spontaneous breathing trial on reintubation rates in critically ill subjects: a retrospective study.BMC pulmonary medicine · 2025Article
- Predictors of weaning failure in ventilated intensive care patients: a systematic evidence map.Critical care (London, England) · 2024Review
- Response to: the association between time definition of reintubation and patient outcomes in critically ill patients-several topics should be noticed.Critical care (London, England) · 2024Article
- The association between time definition of reintubation and patient outcomes in critically ill patients: several topics should be noticed.Critical care (London, England) · 2023Article
- Decannulation criteria in patients with acquired brain injury based on interval forced vital capacity monitoring: a prospective observational study.Frontiers in neurologyArticle
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReintubation is a common complication in critically ill patients requiring mechanical ventilation. Although reintubation has been demonstrated to be associated with patient outcomes, its time definition varies widely among guidelines and in the literature. This study aimed to determine the association between reintubation and patient outcomes as well as the consequences of the time elapsed between extubation and reintubation on patient outcomes.
methodsThis was a multicenter retrospective cohort study of critically ill patients conducted between April 2015 and March 2021. Adult patients who underwent mechanical ventilation and extubation in intensive care units (ICUs) were investigated utilizing the Japanese Intensive Care PAtient Database. The primary and secondary outcomes were in-hospital and ICU mortality. The association between reintubation and clinical outcomes was studied using Cox proportional hazards analysis. Among the patients who underwent reintubation, a Cox proportional hazard analysis was conducted to evaluate patient outcomes according to the number of days from extubation to reintubation.
resultsOverall, 184,705 patients in 75 ICUs were screened, and 1849 patients underwent reintubation among 48,082 extubated patients. After adjustment for potential confounders, multivariable analysis revealed a significant association between reintubation and increased in-hospital and ICU mortality (adjusted hazard ratio [HR] 1.520, 95% confidence interval [CI] 1.359-1.700, and adjusted HR 1.325, 95% CI 1.076-1.633, respectively). Among the reintubated patients, 1037 (56.1%) were reintubated within 24 h after extubation, 418 (22.6%) at 24-48 h, 198 (10.7%) at 48-72 h, 111 (6.0%) at 72-96 h, and 85 (4.6%) at 96-120 h. Multivariable Cox proportional hazard analysis showed that in-hospital and ICU mortality was highest in patients reintubated at 72-96 h (adjusted HR 1.528, 95% CI 1.062-2.197, and adjusted HR 1.334, 95% CI 0.756-2.352, respectively; referenced to reintubation within 24 h).
conclusionsReintubation was associated with a significant increase in in-hospital and ICU mortality. The highest mortality rates were observed in patients who were reintubated between 72 and 96 h after extubation. Further studies are warranted for the optimal observation of extubated patients in clinical practice and to strengthen the evidence for mechanical ventilation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.