ArticleSystematic reviews2023
Prospective longitudinal associations between adverse childhood experiences and adult mental health outcomes: a protocol for a systematic review and meta-analysis.
Article in Systematic reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prospective Longitudinal Associations Between Adverse Childhood Experiences and Adult Mental Health Outcomes: Systematic Review and Meta-Analysis.Trauma, violence & abuse · 2026Pooled it
- Associations between adverse childhood experiences and progression to incident psychiatric disorders in older adults: A 22-year cohort study.Translational psychiatry · 2026Article
- Adverse childhood and adult experiences, intrinsic capacity decline, and subsequent physical-psychological-cognitive multimorbidity: a prospective cohort study from China.The journal of nutrition, health & aging · 2026Article
- Symptom network analysis of depressive and somatic symptoms and suicide risk indicators in treatment-naïve adolescents with first-episode depression.BMC psychiatry · 2026Article
- The mediating effect of alexisomia between childhood abuse and depression/stress in a sample of Lebanese adults: A cross-sectional study.Global mental health (Cambridge, England) · 2026Article
- Associations between adverse childhood experiences and progression to incident psychiatric disorders in older adults: A 22-year cohort study.Research square · 2025Article
- Childhood trauma cortisol and immune cell glucocorticoid transcript levels are associated with increased risk for suicidality in adolescence.Molecular psychiatry · 2025Article
- Article
- Prevalence and impact of adverse childhood experiences and extrafamilial violence: a representative survey of adults in Northern Ireland.BMJ public health · 2025Article
- Exploring the role of bridging nodes linking adverse childhood experiences and psychological risk factors in suicidal ideation among MSM.Scientific reports · 2024Article
- The impact of adverse childhood experiences on mental health, sexual risk behaviors, and alcohol consumption in adulthood.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundResearch cites a strong, dose-response relationship between adverse childhood experiences (ACEs) and poor adult mental health outcomes including anxiety, depression, post-traumatic stress disorder (PTSD), self-harm, suicidality, and psychotic-like experiences.
aimTo systematically investigate the existence and strength of association between ACEs and adult mental health outcomes in prospective longitudinal studies. The review will focus on the outcomes: anxiety, depression, PTSD, self-harm, suicidal ideation, and psychotic-like experiences.
methodsTwelve electronic databases will be searched: Embase, PsycINFO, MEDLINE, and Global Health through the OVID interface. ProQuest will be used to search Public Affairs Information Service (PAIS), Dissertations and Theses, Sociology Database (including Sociological Abstracts and Social Services Abstracts), PTSDpubs (formerly The Published International Literature on Traumatic Stress (PILOTS) Database) and Applied Social Sciences Index and Abstracts (ASSIA). CINAHL, World Health Organisation (WHO) Global Index Medicus, and WHO Violence Info will also be searched. Eligible studies will be double screened, assessed, and their data will be extracted. Any disagreement throughout these processes will be settled by a third reviewer. If enough studies meet the criteria and the methodological quality of each study is sufficient, a meta-analysis will be conducted. ANALYSIS: A narrative synthesis of included studies and the associations between ACEs and adult mental health will be completed. If the number of studies included per mental health outcome is two or more, a multi-level meta-analysis will be completed using odds ratio effect sizes as outcomes. DISCUSSION: This review will contribute to the existing body of literature supporting the long-term effects of ACEs on adult mental health. This review adds to previous reviews that have either synthesised cross-sectional associations between ACEs and mental health outcomes, synthesised longitudinal studies exploring the effect of ACEs on different physical and mental health outcomes or synthesised longitudinal studies exploring the effect of ACEs on the same mental health outcomes using different methods. This review aims to identify methodological weaknesses and knowledge gaps in current literature that can be addressed in future primary studies. SYSTEMATIC REVIEW REGISTRATION: This protocol has been registered in PROSPERO (CRD42021297882).
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