ArticleNature communications2023
Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 60 citations in OpenAlex.
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Cascading Periods of Language-Related Brain Plasticity Across Early Childhood.Developmental science · 2026Article
- Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth.Nature communications · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- White matter structure-function coupling in neonatal brain and its association with Autism-related traits in early childhood.Translational psychiatry · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Cascading periods of language-related brain plasticity across early childhood.bioRxiv : the preprint server for biology · 2026Article
- Personalized whole-brain Ising models with heterogeneous nodes capture differences among brain regions.bioRxiv : the preprint server for biology · 2026Article
- Dual-axis myelination covariance drives the functional connectivity emergence during infancy.Nature communications · 2026Article
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- The development of aperiodic neural activity in the human brain.Nature human behaviour · 2025Article
- A hierarchy of time constants and reliable signal propagation in the marmoset cerebral cortex.Nature communications · 2025Article
- Brain Myelin Covariance Networks: Gradients, Cognition, and Higher-Order Landscape.Behavioral sciences (Basel, Switzerland) · 2025Article
- Quantifying Structure-Function Coupling in the Human Brain using Variational Graph Contrastive Learning.bioRxiv : the preprint server for biology · 2025Article
- Disentangling metabolic and neurovascular timescales supporting cognitive processes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulate that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employ atlas- and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings are consistent across six complementary processing pipelines: 1) SFC and its temporal variance respectively decrease and increase across the unimodal-transmodal and granular-agranular gradients; 2) increased myelination and lower EI-ratio are associated with more rigid SFC and restricted moment-to-moment SFC fluctuations; 3) a gradual shift from EI-ratio to myelination as the principal predictor of SFC occurs when traversing from granular to agranular cortical regions. Collectively, our work delivers a framework to conceptualize structure-function relationships in the human brain, paving the way for an improved understanding of how demyelination and/or EI-imbalances induce reorganization in brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.