ArticleArchives of gerontology and geriatrics2023
Relating depression, anxiety, stress and loneliness to 5-year decline in physical function and frailty.
Article in Archives of gerontology and geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Lagged effects of risk factors on the disability of older adults: A distributed lag non-linear model approach.International journal of nursing sciences · 2026Article
- Study protocol: longitudinal observational study on frailty and mental health.Frontiers in public health · 2026Observational
- Development and external validation of a machine learning model for three-tier disability risk stratification in older adults.Frontiers in public health · 2026Article
- The relationship between disability, anxiety and depression in older adults with chronic disease comorbidities: the mediating role of frailty.BMC geriatrics · 2025Article
- The contribution of depression and anxiety to frailty in men and women: data from a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- Hypothetical Interventions on Frailty Heterogeneous Trajectories of Older Patients with Gastric Cancer Using Parametric G-Formula.Annals of surgical oncology · 2025Observational
- Financial toxicity and quality of life among older adults with cancer: a moderated mediation model of loneliness and social support.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Bidirectional, longitudinal associations between depressive symptoms and IADL/ADL disability in older adults in China: a national cohort study.BMC geriatrics · 2024Article
- The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWhile depression has been associated with physical function decline and worsening frailty in older adults, the impact of other mental health symptoms on physical function and frailty is unknown. The study objective was to determine whether depression, perceived stress, loneliness, and anxiety symptoms affect 5-year physical function and frailty trajectories of older adults.
methodsThe National Social Life, Health, and Aging Project (NSHAP) is a nationally-representative study of adults born between 1920 and 1947. The analysis included data collected in 2010-11 and 2015-16. Mental health symptoms were quantified using NSHAP's measures of anxiety (range:0-21), perceived stress (0-8), depression (0-22), and loneliness (0-6); higher scores indicated worse symptoms. We regressed 2015-16 3 m usual walk time, five-repeated chair stand time or an adapted frailty phenotype scale (0-4) separately on each 2010-11 mental health scale, adjusting for baseline physical function or frailty, demographics, and comorbidities.
resultsIn separate models, every one-point increase on the depression or perceived stress scales was associated with, respectively, a 0.06 s slower (95 % CI: 0.03, 0.10) or 0.09 s slower (95 % CI: 0.01, 0.16) 5-year walk time. Every one-point increase on the depression or perceived stress scales was associated with a 0.15 s slower (95 % CI: 0.06, 0.23) or 0.16 s slower (95 % CI: 0.02, 0.29) 5-year chair stand time. Every one-point increase on the depression scale predicted 0.06 higher log odds of having a worse frailty score 5 years later. Only depression's association with 3 m walk time and chair stands remained significant in models including all four mental health scales. DISCUSSION: Older adults with more depression and to a lesser extent stress symptoms may experience faster physical function decline and worsening frailty. Future work exploring and addressing the mechanisms underlying these relationships are warranted.
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