Evidence map›Paper›PMID 37776539›Full record

ArticleRNA biology2023

Anticodon sequence determines the impact of mistranslating tRNA

Ecaterina Cozma, Megha Rao, Madison Dusick, Julie Genereaux, Ricard A Rodriguez-Mias, Judit Villén, Christopher J Brandl, Matthew D Berg

Open access · goldAbstract read
In one paragraph

Article in RNA biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mistranslating tRNA variants impact the proteome and phosphoproteome ofbioRxiv : the preprint server for biology · 2025
    Article
  5. Natural human tRNARNA (New York, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Mistranslating tRNA variants have anticodon- and sex-specific impacts onbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ecaterina CozmaDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0003-4446-8302
Megha RaoDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-2096-1322
Madison DusickDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-1958-8671
Julie GenereauxDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Ricard A Rodriguez-MiasDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7960-6387
Judit VillénDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1005-1739
Christopher J BrandlDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0001-8015-9668
Matthew D BergDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7924-9241
Western University · CAUniversity of Washington · US

Funding

Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9M
Towards a comprehensive roadmap of cellular signaling.R35GM119536 · NIGMS · UNIVERSITY OF WASHINGTON · PI VILLEN, JUDIT · 2016 to 2020
$2.2M
NHGRI NIH HHS RM1 HG010461NIGMS NIH HHS R35 GM119536
6 · The paper itself

Abstract

Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic message is incorporated into proteins and has applications in biotechnology, therapeutics and is relevant to disease. Since the alanyl-tRNA synthetase uniquely recognizes a G3:U70 base pair in tRNA

Indexed as

AnticodonRNA, Transfer, AlaAlanineCodonProtein BiosynthesisRNA, TransferAlanineAnticodonCodonRNA, TransferRNA, Transfer, Alaexpanded decodinggenetic codeMistranslationtRNAAlatRNA biology

Identifiers

PMID37776539
PMCPMC10543346
OpenAlexW4387215274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.