Evidence map›Paper›PMID 37776489›Full record

ArticleTranslational stroke research2024

Comparison of Long-Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management.

Changyu Lu, Heze Han, Li Ma, Ruinan Li, Zhipeng Li, Haibin Zhang, Kexin Yuan, Yukun Zhang, Anqi Li, Ke Wang and 25 more

Erratum issuedAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Changyu Lu *Department of Neurosurgery, Peking University International Hospital, Beijing, China.
Heze Han *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Li MaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ruinan LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhipeng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Haibin ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Kexin YuanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yukun ZhangDepartment of Neurosurgery, Peking University International Hospital, Beijing, China.
Anqi LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ke WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yang ZhaoDepartment of Neurosurgery, Peking University International Hospital, Beijing, China.
Weitao JinDepartment of Neurosurgery, Peking University International Hospital, Beijing, China.
Dezhi GaoDepartment of Gamma-Knife Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hengwei JinDepartment of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiangyu MengDepartment of Neurosurgery, The First Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.
Debin YanDepartment of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Runting LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fa LinDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qiang HaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hao WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xun YeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuai KangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jun PuFirst Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
Zhiyong ShiDepartment of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated to Nanjing University, Nanjing, Jiangsu, China.
Xiaofeng ChaoDepartment of Neurosurgery, The Second Affiliated Hospital of Xuzhou Medical University, Jiangsu, China.
Zhengfeng LinDepartment of Neurosurgery, The First People's Hospital of Qinzhou, Guangxi, China.
Junlin LuDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Youxiang LiDepartment of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuanli ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shibin SunDepartment of Gamma-Knife Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaolin ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. cxl_bjtth@163.com.
Weiwei ChenDepartment of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China. 158527400@qq.com.
Yu ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. chenyu_tiantan@126.com.
Shuo WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. captain9858@126.com.
Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH)

Funding

National Key Research and Development Program of China 2021YFC2501101 and 2020YFC2004701National Natural Science Foundation of China 81771234, 82071302National Natural Science Foundation of China 82202244
6 · The paper itself

Abstract

Brain arteriovenous malformations (AVMs) with a diffuse nidus structure present a therapeutic challenge due to their complexity and elevated risk of hemorrhagic events. This study examines the long-term effectiveness of interventional therapy versus conservative management in reducing hemorrhagic stroke or death in patients with ruptured diffuse AVMs. The analysis was conducted based on a multi-institutional database in China. Patients were divided into two groups: conservative management and interventional therapy. Using propensity score matching, patients were compared for the primary outcome of hemorrhagic stroke or death and the secondary outcomes of disability and neurofunctional decline. Out of 4286 consecutive AVMs in the registry, 901 patients were eligible. After matching, 70 pairs of patients remained with a median follow-up of 4.0 years. The conservative management group showed a trend toward higher rates of the primary outcome compared to the interventional group (4.15 vs. 1.87 per 100 patient-years, P = 0.090). While not statistically significant, intervention reduced the risk of hemorrhagic stroke or death by 55% (HR, 0.45 [95% CI 0.18-1.14], P = 0.094). No significant differences were observed in secondary outcomes of disability (OR, 0.89 [95% CI 0.35-2.26], P = 0.813) and neurofunctional decline (OR, 0.65 [95% CI 0.26 -1.63], P = 0.355). Subgroup analysis revealed particular benefits in interventional therapy for AVMs with a supplemented S-M grade of II-VI (HR, 0.10 [95% CI 0.01-0.79], P = 0.029). This study suggests a trend toward lower long-term hemorrhagic risks with intervention when compared to conservative management in ruptured diffuse AVMs, especially within supplemented S-M grade II-VI subgroups. No evidence indicated that interventional approaches worsen neurofunctional outcomes.

Indexed as

Conservative TreatmentIntracranial Arteriovenous MalformationsAdultChinaEmbolization, TherapeuticFemaleFollow-Up StudiesHumansMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeYoung AdultArteriovenous malformationsConservative managementDiffusenessHemorrhagic strokeInterventional therapy

Identifiers

PMID37776489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.