ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2024
Relationship between multimorbidity, functional limitation, and quality of life among middle-aged and older adults: findings from the longitudinal analysis of the 2013-2020 Survey of Health, Ageing, and Retirement in Europe (SHARE).
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 26 citations in OpenAlex.
- Health-related quality of life among older adults following acute hospitalization: longitudinal analysis of a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Trial
- The association between multimorbidity and needs-based quality of life in primary care: a cross-sectional questionnaire study.Scandinavian journal of primary health care · 2026Article
- Multimorbidity and health related quality of life in midlife - a longitudinal study from Northern Finland Birth Cohort 1966.Scandinavian journal of primary health care · 2026Article
- Association Between Physical Activity Levels and Life Functioning in Korean Older Adults: A Cross-Sectional Analysis of the 2024 Korea National Health and Nutrition Examination Survey.Healthcare (Basel, Switzerland) · 2026Article
- Life-course patterning of MLTC clusters and their patient-centred burden in depression: a population-based study using real-world data.BMJ mental health · 2026Article
- Understanding Well-Being in Daily Life: Informal Social Support, Depression Risk, and Life Satisfaction Among Chinese Older Adults with Disabilities.Behavioral sciences (Basel, Switzerland) · 2026Article
- Diurnal temperature range and daily mean temperature in relation to multimorbidity among middle-aged or older Chinese adults: insights from the CHARLS.BMC public health · 2026Article
- Multimorbidity burden is associated with lower perceived health and life satisfaction in urban South Africa.Scientific reports · 2026Article
- Patterns of Vulnerability: Frailty, Multimorbidity, and Physical Health-Related Quality of Life in Institutionalised Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- Clinical Performance and Calibration of the PROFUND Index in Hospitalized and Ambulatory Complex Chronic Patients: A Real-World Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Relative Leukocyte Telomere Length Is Associated with Multimorbidity Burden in Older Adults: Evidence for Sex-Specific Associations.International journal of molecular sciences · 2026Article
- European training requirements in geriatric medicine 2025: driving competency-based education and harmonisation across Europe.European geriatric medicine · 2026Article
- Social Well-Being and Quality of Life Among Older Adults in Latvia-A Country with the Lowest Healthy Life Years in the EU.Medicina (Kaunas, Lithuania) · 2026Article
- Impact of disability and selected factors on the quality of life in the older people in southeastern Poland - a cross-sectional study.BMC public health · 2026Article
- Analysing the impact of complex multimorbidity on health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Quality of life for middle and older aged people with chronic conditions in primary care: a cross-sectional study.BMC primary care · 2026Observational
- The impact of physical exercise on medical expenditure among middle-aged and older adults: digital literacy as a moderating variable.Frontiers in public health · 2026Article
- Assessment of Functional Capacity and Its Sociodemographic and Health Determinants in Older Adults from a Region of Peru.Risk management and healthcare policy · 2026Article
- Nurses as guardians of time: the hidden clinical value of continuous care in geriatrics.Frontiers in public health · 2026Review
- Factors Related to Quality of Life Among Older Adults with Family Care Vulnerability in Semi-Urban Areas of Thailand.Journal of multidisciplinary healthcare · 2026Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
purposeThe increased burden of multimorbidity is restricting individuals' ability to live autonomously, leading to a poorer quality of life. This study estimated trajectories of functional limitation and quality of life among middle-aged (ages 50 to 64 years) and older (aged 65 years and older) individuals with and without multimorbidity. We also assessed differences in the relationship between these two trajectories by multimorbidity status and separately for each age cohort.
methodsData originated from the Survey of Health, Ageing, and Retirement in Europe (SHARE). In Luxembourg, data were obtained between 2013 and 2020, involving 1,585 respondents ≥ 50 years of age. Multimorbidity was defined as a self-reported diagnosis of two or more out of 16 chronic conditions; functional limitation was assessed by a combined (Instrumental) Activities of Daily Living (ADL/IADLI) scale; and to measure quality of life, we used the Control, Autonomy, Self-Realization, and Pleasure (CASP-12) scale. Latent growth curve modelling techniques were used to conduct the analysis where repeated measures of quality of life and functional limitation were treated as continuous and zero-inflated count variables, respectively. The model was assessed separately in each age cohort, controlling for the baseline covariates, and the estimates from the two cohorts were presented as components of a synthetic cohort covering the life course from the age of 50.
resultsMiddle-aged and older adults living with multimorbidity experienced poorer quality of life throughout the life course and were at a higher risk of functional limitation than those without multimorbidity. At baseline, functional limitation had a negative impact on quality of life. Furthermore, among middle-aged adults without multimorbidity and older adults with multimorbidity, an increase in the number of functional limitations led to a decline in quality of life. These results imply that the impact of multimorbidity on functional limitation and quality of life may vary across the life course.
conclusionUsing novel methodological techniques, this study contributes to a better understanding of the longitudinal relationship between functional limitation and quality of life among individuals with and without multimorbidity and how this relationship changes across the life course. Our findings suggest that lowering the risk of having multimorbidity can decrease functional limitation and increase quality of life.
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