Evidence map›Paper›PMID 37776339›Full record

ArticleLangenbeck's archives of surgery2023

Multi-visceral resection for left-sided pancreatic ductal adenocarcinoma: a multicenter retrospective analysis from European countries.

Cecilia Ferrari, Piera Leon, Massimo Falconi, Ugo Boggi, Tullio Piardi, Laurent Sulpice, Davide Cavaliere, Edoardo Rosso, Mircea Chirica, Ferruccio Ravazzoni and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cecilia FerrariHPB and Transplant Unit, University of Montpellier, Montpellier, France. ferraricecilia.unige@gmail.com.
Piera LeonHPB and Transplant Unit, University of Montpellier, Montpellier, France.
Massimo FalconiChirurgia Pancreatica, IRCCS Ospedale San Raffaele, Milano, Italy.
Ugo BoggiChirurgia HPB e Trapianto di Fegato, Ospedale Cisanello, Università degli Studi di Pisa, Pisa, Italy.
Tullio PiardiReims University Hospital, Reims, France.
Laurent SulpiceRennes University Hospital, Rennes, France.
Davide CavaliereOspedale di Forlì, Forlì, Italy.
Edoardo RossoDepartment of Surgery, Istituto Fondazione Poliambulanza, Brescia, Italy.
Mircea ChiricaGrenoble Alpes University Hospital, Grenoble, France.
Ferruccio RavazzoniOspedale di Alessandria, Alessandria, Italy.
Riccardo MemeoUniversity of Bari, Bari, Italy.
Patrick PessauxCHU Strasbourg University Hospital, Strasbourg, France.
Vito De BlasiService de Chirurgie Générale et Mini-Invasive, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Matteo MascheriniOspedale Policlinico San Martino, Genova, Italy.
Franco De CianOspedale Policlinico San Martino, Genova, Italy.
Francis NavarroHPB and Transplant Unit, University of Montpellier, Montpellier, France.
Fabrizio PanaroHPB and Transplant Unit, University of Montpellier, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to delayed diagnosis and a lower surgical indication rate, left-sided pancreatic ductal adenocarcinoma (PDAC) is often associated with a poor prognosis in comparison to pancreatic head tumors. Multi-visceral resections (MVR) associated with distal pancreatectomy could be proposed for patients presenting with locally infiltrating disease.

methodsWe retrospectively analyzed a multi-centric cohort of left-sided PDAC patients operated on from 2009 to 2020. Thirteen European high-volume HPB centers participated in this study. We analyzed patients who underwent distal pancreatectomy (DP) associated with MVR and compared them to standard DP patients.

resultsAmong 258 patients treated curatively for PDAC of the body and tail, 28 patients successfully underwent MVR. A longer operative time was observed in the MVR group (295 min +/- 74 vs. 250 min +/- 96, p= 0.248). The post-operative complication rate was comparable between the two groups (46.4% in the MVR group vs. 62.2% in the control group, p= 0.108). The incidence of positive margin (R1) was similar between the two groups (28.6% vs. 26.6%; p=0.827). After a median follow-up of 25 (9-111) months, overall survival was comparable between the two groups (p= 0.519).

conclusionsMulti-visceral resection in left-sided pancreatic ductal adenocarcinoma is safe and feasible and should be considered in selected cases as it seems to provide acceptable surgical and oncological outcomes.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsHumansPancreasPancreatectomyPostoperative ComplicationsRetrospective StudiesDistal pancreatectomyMulti-visceral resectionOverall survivalPancreatic ductal cancerPancreatic fistulaPancreatic surgeryPostoperative complications

Identifiers

PMID37776339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.