ReviewAdvanced healthcare materials2024
Shell Formulation in Soft Gelatin Capsules: Design and Characterization.
Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Alkylsuccinylated Bentonite-GelMA Hybrid Hydrogels for Enhanced Mechanics and Osteogenic Drug Delivery.ACS omega · 2026Article
- A Framework for Developing Intake and Use Guidance for Dietary Supplement Bioactives.Advances in nutrition (Bethesda, Md.) · 2026Review
- Translational Barriers to Pharmaceutical Excipient Readiness in Marine-Derived Polymers.Polymers · 2026Review
- Religious and Cultural Considerations for the Dermatologic Care of Muslim Communities: A Narrative Review of Patient-Centered Strategies.American journal of clinical dermatology · 2026Review
- Integrating Moisture Sorption, Hygroscopic Kinetics, and Mechanical Analysis to Forecast Leakage and Shelf Life of Gelatin Soft Capsules.Gels (Basel, Switzerland) · 2026Article
- Cell encapsulated biomaterials for translational medicine.Bioactive materials · 2026Review
- Optimization and validation of the real-time polymerase chain reaction protocol for porcine gelatin detection in processed food and cosmetic products.Open veterinary journal · 2026Article
- Understanding the Impact of Sustainable Pharmaceutical Packaging on the Chemical Stability of Silodosin.Pharmaceutics · 2025Article
- Expert Perspectives on Enhancing Analytical Methods for Multi-Ingredient Dietary Supplements (MIDS): A Qualitative Study.Foods (Basel, Switzerland) · 2025Article
- How can the leakage phenomenon of gelatin-based soft capsule shells be estimated?BMC chemistry · 2025Article
- Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Capsule robots for the monitoring, diagnosis, and treatment of intestinal diseases.Materials today. Bio · 2024Review
- NIR-Guided Coating Optimization of Omega-3 Fatty Acid Mini Soft Capsules with Pitavastatin and Ezetimibe.Pharmaceutics · 2024Article
- Bioprinting of gelatin-based materials for orthopedic application.Frontiers in bioengineering and biotechnology · 2024Review
- Preparation of altrenogest soft capsules and their bioequivalence in gilts.Frontiers in veterinary science · 2024Article
- Shell Formulation in Soft Gelatin Capsules: Design and Characterization.Advanced healthcare materials · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Soft gelatin capsules (SGCs) are the most widely used pharmaceutical form after tablets. The active components, active pharmaceutical ingredients (APIs), or nutrients are dissolved, dispersed, or suspended in a liquid or semisolid fill, which is covered with a gelatin shell. Several factors can modify the properties of the gelatin shell and subsequently affect their operative handling during manufacturing process and the stability of the soft gelatin capsules. Three elements appear to be crucial: the shell formulation (type and content of the different components such as gelatins-source, extraction method-plasticizers, or additives); the manufacture and storage conditions (temperature, humidity, light) as well as the interactions between fill-shell formulas. Mechanical and thermal analysis arise as straightforward but highly useful tools to monitor the properties of the gelatin shell. This review provides an updated overview on the shell formulation and design. Additionally, it presents the uses of mechanical and thermal techniques to characterize and evaluate the impact of different parameters on the gelatin behavior over the production and stability of these pharmaceutical forms. This will help to detect changes that are yet not visible by visual inspection ensuring a suitable finished product over its shelf-life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.