Evidence map›Paper›PMID 37775784›Full record

Observational studyItalian journal of pediatrics2023

Leading reasons for antibiotic prescriptions in pediatric respiratory infections: influence of fever in a primary care setting.

Marina Picca, Romeo Carrozzo, Gregorio Paolo Milani, Antonio Corsello, Marina Macchi, Roberto Buzzetti, Paola Marchisio, Chiara Mameli

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Factors behind Antibiotic Therapy: A Survey of Primary Care Pediatricians in Lombardy.International journal of environmental research and public health · 2024
    Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marina Picca *Italian Primary Care Paediatrics Society (SICuPP), Lombardy, Italy.
Romeo Carrozzo *Italian Primary Care Paediatrics Society (SICuPP), Lombardy, Italy.
Gregorio Paolo Milani *Department of Health Science and Community Health, University of Milan, Milan, Italy.
Antonio CorselloDepartment of Health Science and Community Health, University of Milan, Milan, Italy. antonio.corsello@gmail.com.ORCID http://orcid.org/0000-0003-4578-0066
Marina MacchiDepartment of Health Science and Community Health, University of Milan, Milan, Italy.
Roberto BuzzettiClinical epidemiologist, Bergamo, Italy.
Paola Marchisio *Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Chiara Mameli *Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotic overuse in children is a significant public health concern, as it can lead to the emergence and spread of antibiotic-resistant bacteria. Although respiratory infections account for most antibiotic prescriptions in children, many of these infections are viral and do not require antibiotics. In this study, we aimed to investigate the use of antibiotics in children with respiratory infections in a primary care setting and to explore the possible role of fever on antibiotic prescription.

methodsWe conducted a prospective observational study that evaluated preschool children aged 0-5 years who were assessed by their primary care pediatricians for respiratory infectious diseases between October 2019 and March 2021. The study involved 69 public primary care pediatricians and a total of 678 pediatric episodes for respiratory infections.

resultsAmoxicillin/clavulanate was the most frequently prescribed drug. Bronchitis accounted for most of inappropriate antibiotic prescriptions (73%). Furthermore, the presence of fever was associated with a ~ 300% increase in the likelihood of prescribing antibiotics for respiratory infections that do not typically require antibiotics.

conclusionOur findings emphasize the need for adherence to international guidelines and recommendations in the primary care of children to reduce unnecessary antibiotic use and prevent the development of antibiotic resistance. This study also underscores the potential relevance of new studies to evaluate antibiotic prescription attitudes in other clinical settings and geographical areas.

Indexed as

BronchitisRespiratory Tract InfectionsAnti-Bacterial AgentsChildChild, PreschoolDrug PrescriptionsFeverHumansPractice Patterns, Physicians'Primary Health CareAnti-Bacterial AgentsAmoxicillinAntibiotic stewardshipChildren fever phobiaCovid-19 pandemicDrugs over-prescriptionPrimary pediatric careRespiratory infections

Identifiers

PMID37775784
PMCPMC10541709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.