ArticleCardiovascular diabetology2023
Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 28 citations in OpenAlex.
- The negative association between C-reactive protein-albumin-lymphocyte index and cardiovascular disease.The Journal of international medical research · 2026Article
- Clinical prediction model of invalid recanalization after complete reperfusion after thrombectomy in acute ischemic stroke patients: a large retrospective study.Journal of neurointerventional surgery · 2026Article
- Association of prognostic nutritional index with the risk of all-cause mortality and cardiovascular events in patients with diabetes-related foot ulcers: a non-linear relationship mediated by eGFR.Frontiers in nutrition · 2026Article
- Serum magnesium and major adverse cardiovascular events in patients with diabetic foot ulcers: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- The shared biomarkers and molecular mechanisms of systemic lupus erythematosus and type 2 diabetes.PloS one · 2026Article
- From deep learning discovery to clinical validation: a new composite marker predicts mortality in type 2 diabetes.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association.Scientific reports · 2025Article
- Association between neutrophil-to-lymphocyte ratio and all-cause and cardiovascular mortality among adults with cancer from NHANES 2005-2018: a retrospective cohort study.Frontiers in oncology · 2025Article
- Predictive value of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) for all-cause and cardiovascular mortality with non-hyperhomocysteinemia: evidence from NHANES 1999 to 2006.Frontiers in nutrition · 2025Article
- Article
- Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk.Frontiers in nutrition · 2025Article
- Fibrosis-4 index as a predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease.PloS one · 2025Article
- Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999-2018.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Association between vascular aging and cardiovascular-kidney-metabolic syndrome.Frontiers in endocrinology · 2025Article
- The L-shaped association between body roundness index and all-cause mortality in osteoporotic patients: a cohort study based on NHANES data.Frontiers in nutrition · 2025Article
- Elevated Platelet-to-Lymphocyte Ratio as a Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Individuals.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Elevated neutrophil percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality among individuals with diabetes.Scientific reports · 2024Article
- The Neutrophil Percentage-to-Albumin Ratio as a Biomarker for All-Cause and Diabetes-Cause Mortality Among Diabetes Patients: Evidence From the NHANES 1988-2018.Journal of clinical laboratory analysis · 2024Article
- Association between serum β2-microglobulin and left ventricular hypertrophy in patients with type 2 diabetes mellitus: A cross-sectional study.Journal of diabetes · 2024Article
- The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension.Cardiovascular diabetology · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiabetes poses a significant threat to human health. There is a lack of large-scale cohort studies to explore the association between mortality risk and indicators beyond blood glucose monitoring in diabetic populations.
methodsMultivariable Cox proportional hazards regression models were performed to investigate the association of 13 blood biomarkers with mortality risk in the National Health and Nutrition Examination Survey (NHANES) and biomarker levels were log-transformed and correlated with mortality.
resultsDuring a median follow-up of 7.42 years, 1783 diabetic patients were enrolled. Compared to traditional risk factors, the addition of hs-cTnT, hs-cTnI, NT-proBNP, creatinine, cystatin C, and β-2 microglobulin biomarkers increased the predictive ability for all-cause mortality by 56.4%, 29.5%, 38.1%, 18.8%, 35.7%, and 41.3%, respectively. However, the inclusion of blood glucose monitoring had no impact on the prediction of all-cause mortality. Compared with the 1st quartiles of creatinine and Cystatin C, the risk of diabetes mortality were higher in the highest quartiles (HR: 5.16, 95% CI: 1.87-14.22; HR: 10.06, 95% CI: 4.20-24.13).
conclusionsIn the diabetic population, elevated plasma levels of hs-cTnT, hs-cTnI, NT-proBNP, creatinine, cystatin C, and β-2 microglobulin serve as robust and straightforward predictors of long-term mortality compared to blood glucose levels and HbA1c values. Creatinine and cystatin C stand out as more precise markers for predicting diabetes mortality prior to blood glucose monitoring.
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