Evidence map›Paper›PMID 37775647›Full record

ReviewBasic research in cardiology2023

Giant mitochondria in cardiomyocytes: cellular architecture in health and disease.

Amy Li, Gerald J Shami, Lisa Griffiths, Sean Lal, Helen Irving, Filip Braet

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Basic research in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

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  18. Mitochondrial Kinase Signaling for Cardioprotection.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Amy LiDepartment of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia. amy.li@torrens.edu.au.ORCID http://orcid.org/0000-0001-5413-3771
Gerald J ShamiSchool of Medical Sciences (Molecular and Cellular Biomedicine), The University of Sydney, Camperdown, NSW, Australia.
Lisa GriffithsAnatomical Pathology, PathWest, QEII Medical Centre, Nedlands, WA, Australia.
Sean LalSchool of Medical Sciences, The University of Sydney, Camperdown, NSW, Australia.
Helen IrvingDepartment of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Filip BraetSchool of Medical Sciences (Molecular and Cellular Biomedicine), The University of Sydney, Camperdown, NSW, Australia. filip.braet@sydney.edu.au.
The University of Sydney · AULa Trobe University · AUQueen Elizabeth II Medical Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.

Indexed as

CardiomyopathiesMyocytes, CardiacHumansMitochondriaMitochondria, HeartMitochondrial SwellingMyocardiumCardiomyopathyGiant and megamitochondriaHistopathological markerMitochondrial aberrationsMitochondrion pathophysiologyMuscle disease

Identifiers

PMID37775647
PMCPMC10541842
OpenAlexW4387166899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.