ArticleNeurology2023
Pattern of Brain Parenchymal Damage Related to Cerebral Small Vessel Disease in Carriers of Rare
Open access · greenAbstract read
In one paragraph
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis.Stroke and vascular neurology · 2026Article
- Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis.Frontiers in aging neuroscience · 2026Article
- The Kashima Scan Study 2: a protocol for a prospective observational cohort study of cerebral small vessel disease in neurologically healthy adults.Environmental health and preventive medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Zi-Yue LiuFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0002-3246-2301
Fei-Fei ZhaiFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jing-Yi LiuFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yi-Jun ZhouFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0001-9248-234X
Mei-Jun ShuFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0001-7584-5508
Xiao-Hong HuangFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0009-0004-0122-0416
Fei HanFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ming-Li LiFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0001-8456-0686
Li-Xin ZhouFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jun NiFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ming YaoFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0003-2104-3248
Shu-Yang ZhangFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0002-1532-0029
Li-Ying CuiFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0001-9223-6659
Zheng-Yu JinFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yi-Cheng ZhuFrom the Department of Neurology (Z.-Y.L., F.-F.Z., M.-J.S., X.-H.H., F.H., L.-X.Z., J.N., M.Y., L.-Y.C., Y.-C.Z.); Department of Radiology (J.-Y.L., Y.-J.Z., M.-L.L., Z.-Y.J.); and Department of Cardiology (S.-Y.Z.), State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. zhuych910@163.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPrevious studies reported that carriers of rare
methodsAs part of a community-based cohort, we included participants with complete whole-exome sequencing and brain MRI in the baseline analysis. All participants were invited for a 5-year follow-up MRI, and those who did not complete the follow-up were excluded from the longitudinal analysis.
resultsA total of 1,054 participants were included in baseline analysis (13.56% carried rare DISCUSSION: Individuals with rare
Indexed as
Brain InjuriesCerebral Small Vessel DiseasesWhite MatterAtrophyBrainHumansMagnetic Resonance ImagingNeuroimagingReceptor, Notch3NOTCH3 protein, humanReceptor, Notch3
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.