ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Evidence That Ultrafast Nonquantal Transmission Underlies Synchronized Vestibular Action Potential Generation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Autism associatedbioRxiv : the preprint server for biology · 2026Article
- Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils.Neurobiology of aging · 2026Article
- Persistence of vestibular function in the absence of glutamatergic transmission from hair cells.Scientific reports · 2026Article
- Multiscale Integration of Acceleration and Jerk Sensing in the Vestibular System.Audiology research · 2026Review
- Functional contributions of quantal and non-quantal hair cell synaptic transmission in the vestibular periphery.bioRxiv : the preprint server for biology · 2025Article
- A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla.The Journal of comparative neurology · 2025Article
- Close Packing of Cells in Vestibular Epithelia Supports Local Electrical Potentials that Reduce Latency of Action Potential Generation.bioRxiv : the preprint server for biology · 2025Article
- KbioRxiv : the preprint server for biology · 2025Article
- The neural basis of vestibular evoked myogenic potentials. The cVEMP is a specific indicator of saccular function.Frontiers in neurology · 2025Review
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- The potassium channel subunit KeLife · 2024Article
- The potassium channel subunit KbioRxiv : the preprint server for biology · 2024Article
- Simultaneous recordings from vestibular Type I hair cells and their calyceal afferents in mice.Frontiers in neurology · 2024Article
- Electrophysiological properties of vestibular hair cells isolated from human crista.Frontiers in neurology · 2024Article
- Vestibular afferent neurons develop normally in the absence of quantal/glutamatergic input.Frontiers in neurology · 2024Article
- Vestibular Testing-New Physiological Results for the Optimization of Clinical VEMP Stimuli.Audiology research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Amniotes evolved a unique postsynaptic terminal in the inner ear vestibular organs called the calyx that receives both quantal and nonquantal (NQ) synaptic inputs from Type I sensory hair cells. The nonquantal synaptic current includes an ultrafast component that has been hypothesized to underlie the exceptionally high synchronization index (vector strength) of vestibular afferent neurons in response to sound and vibration. Here, we present three lines of evidence supporting the hypothesis that nonquantal transmission is responsible for synchronized vestibular action potentials of short latency in the guinea pig utricle of either sex. First, synchronized vestibular nerve responses are unchanged after administration of the AMPA receptor antagonist CNQX, while auditory nerve responses are completely abolished. Second, stimulus evoked vestibular nerve compound action potentials (vCAP) are shown to occur without measurable synaptic delay and three times shorter than the latency of auditory nerve compound action potentials (cCAP), relative to the generation of extracellular receptor potentials. Third, paired-pulse stimuli designed to deplete the readily releasable pool (RRP) of synaptic vesicles in hair cells reveal forward masking in guinea pig auditory cCAPs, but a complete lack of forward masking in vestibular vCAPs. Results support the conclusion that the fast component of nonquantal transmission at calyceal synapses is indefatigable and responsible for ultrafast responses of vestibular organs evoked by transient stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.