Evidence map›Paper›PMID 37774695›Full record

ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2023

Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test.

Matthew D Hirschhorn, Jonathan E M Lawley, Andrew J Roof, Arthur P T Johnson, William A Stoddard, Randy M Stevens, Joseph Rossano, Francisco Arabia, Vakhtang Tchantchaleishvili, H Todd Massey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew D HirschhornFrom the BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.
Jonathan E M LawleyDepartments of Biomedical and Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York.
Andrew J RoofDepartments of Biomedical and Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York.
Arthur P T JohnsonDepartments of Biomedical and Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York.
William A StoddardDepartments of Biomedical and Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York.
Randy M StevensDivision of Pediatrics, College of Medicine, St. Christopher's Hospital for Children, Drexel University, Philadelphia, Pennsylvania.
Joseph RossanoDivision of Cardiology, Pediatric Heart Failure & Transplant Program, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Francisco ArabiaAdvanced Heart Program, Banner University Medical Group, Division of Cardiothoracic Surgery, University of Arizona College of Medicine, Tucson, Arizona.
Vakhtang TchantchaleishviliDivision of Cardiac Surgery, Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
H Todd MasseyDivision of Cardiac Surgery, Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Steven W DayDepartments of Biomedical and Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, New York.
Amy L ThrockmortonFrom the BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.

Funding

Multifunctional VAD Technology for High-Risk Pediatric PatientsR01HL153536 · NHLBI · DREXEL UNIVERSITY · PI THROCKMORTON, AMY · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL153536
6 · The paper itself

Abstract

To address the unmet clinical need for pediatric circulatory support, we are developing an operationally versatile, hybrid, continuous-flow, total artificial heart ("Dragon Heart"). This device integrates a magnetically levitated axial and centrifugal blood pump. Here, we utilized a validated axial flow pump, and we focused on the development of the centrifugal pump. A motor was integrated to drive the centrifugal pump, achieving 50% size reduction. The motor design was simulated by finite element analysis, and pump design improvement was attained by computational fluid dynamics. A prototype centrifugal pump was constructed from biocompatible 3D printed parts for the housing and machined metal parts for the drive system. Centrifugal prototype testing was conducted using water and then bovine blood. The fully combined device ( i.e. , axial pump nested inside of the centrifugal pump) was tested to ensure proper operation. We demonstrated the hydraulic performance of the two pumps operating in tandem, and we found that the centrifugal blood pump performance was not adversely impacted by the simultaneous operation of the axial blood pump. The current iteration of this design achieved a range of operation overlapping our target range. Future design iterations will further reduce size and incorporate complete and active magnetic levitation.

Indexed as

Heart, ArtificialHeart-Assist DevicesHeart FailureAnimalsCattleChildEquipment DesignHumansHydrodynamicsProsthesis Design

Identifiers

PMID37774695
PMCPMC12512218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.