ArticleEnvironment international2023
The association of long-term exposure to criteria air pollutants, fine particulate matter components, and airborne trace metals with late-life brain amyloid burden in the Atherosclerosis Risk in Communities (ARIC) study.
Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Reduced organic nitrogen compounds dominate the toxicity of PMScience advances · 2026Article
- Social determinants of health across the lifecourse and chronic disease risk: available data and seminal findings from the Atherosclerosis Risk in Communities (ARIC) Study.American journal of epidemiology · 2026Review
- Accounting for Exposure Measurement Error in Gridded Air Pollution Estimates in Assessing the Association of PMEnvironmental science & technology · 2026Article
- [Resveratrol protects barrier function of mouse brain microvascular endothelial cell monolayers with oxygen/glucose deprivation and PMNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Ambient air pollution and incident dementia: exploration of relevant exposure windows.Environmental research · 2025Article
- Association of midlife air pollution and road proximity exposure with 29-year cognitive decline.Neurotoxicology · 2025Article
- Iron Trace Elements Concentration in PMBiomedicines · 2024Article
- Association of Gaseous Ambient Air Pollution and Dementia-Related Neuroimaging Markers in the ARIC Cohort, Comparing Exposure Estimation Methods and Confounding by Study Site.Environmental health perspectives · 2024Article
- Comparison ofEnvironmental health perspectives · 2024Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundStudies suggest associations between long-term ambient air pollution exposure and outcomes related to Alzheimer's disease (AD). Whether a link exists between pollutants and brain amyloid accumulation, a biomarker of AD, is unclear. We assessed whether long-term air pollutant exposures are associated with late-life brain amyloid deposition in Atherosclerosis Risk in Communities (ARIC) study participants.
methodsWe used a chemical transport model with data fusion to estimate ambient concentrations of PM
resultsAt PET imaging, eligible participants (N = 318) had a mean age of 78 years, 56% were female, 43% were Black, and 27% had mild cognitive impairment. We did not find evidence of associations between long-term exposure to any pollutant and brain amyloid positivity in adjusted models. Findings were materially unchanged in sensitivity analyses using alternate air pollution estimation approaches for PM
conclusionsAir pollution may impact cognition and dementia independent of amyloid accumulation, though whether air pollution influences AD pathogenesis later in the disease course or at higher exposure levels deserves further consideration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.