Evidence map›Paper›PMID 37774412›Full record

ArticleACS infectious diseases2023

A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria.

Joshua M Werman, Yu-Ching Chen, Tianao Yuan, Xinxin Yang, Nicole S Sampson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joshua M WermanDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0002-8521-7369
Yu-Ching ChenProgram in Biochemistry and Structural Biology, Stony Brook University, Stony Brook, New York 11794-5215, United States.ORCID 0000-0002-0005-0804
Tianao YuanDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0002-4700-8654
Xinxin YangDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0002-5162-5030
Nicole S SampsonDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0002-2835-7760
Stony Brook University · USUniversity of Rochester · US

Funding

The Role of Schwann Cell Lipid Droplets In Neuropathology of LeprosyR01AI141526 · NIAID · COLORADO STATE UNIVERSITY · PI BELISLE, JOHN T, PESSOLANI, MARIA CRISTINA VIDAL · 2019 to 2023
$3.1M
Validating cholesterol-mediated Mycobacterium tuberculosis resistance to oxidative stress as a drug targetR01AI134054 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S · 2017 to 2021
$2.0M
CLC NIH HHS 75N90019D00005NIAID NIH HHS R01 AI134054NIAID NIH HHS R01 AI141526
6 · The paper itself

Abstract

By illuminating key 6-azasteroid-protein interactions in both

Indexed as

Mycobacterium marinumMycobacterium tuberculosisAntitubercular AgentsAzasteroidsBacterial ProteinsAntitubercular AgentsAzasteroidsBacterial Proteinsclick chemistryinhibitoroxidative stressphotoaffinity labelpotentiatorsynergy

Identifiers

PMID37774412
PMCPMC10580313
OpenAlexW4387161421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.