ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Visual search in Alzheimer's disease and amnestic mild cognitive impairment: An eye-tracking study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study.JMIR mHealth and uHealth · 2026Article
- Associations of Social Determinants of Health Scores with Visual Impairment and Premature Death in Visually Impaired Adults: Insights from CHARLS-A Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Article
- Combining Linguistic, Behavioral and Visuospatial Measures to Characterize Multidomain Impairment in Dementia.Brain sciences · 2026Article
- A novel eye-tracking digital marker outperforms plasma biomarkers in detecting cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Tracking the eyes to track decline: Global eye movement similarity as a novel neuropsychological marker of mild cognitive impairment.GeroScience · 2026Article
- Age-dependent vulnerability to spatial memory interference in APP/PS1 mice.Frontiers in aging neuroscience · 2026Article
- Joint trajectories of objective physical function and cognition and risk of incident dementia: a population-based cohort study.Frontiers in psychiatry · 2026Article
- Article
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- An accessible and efficient mobile eye-tracking application for community-based cognitive impairment screening in China.Alzheimer's research & therapy · 2025Article
- Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-genetic circuit mapping.Neurobiology of disease · 2025Review
- A Comprehensive Framework for Eye Tracking: Methods, Tools, Applications, and Cross-Platform Evaluation.Journal of eye movement research · 2025Review
- Non-Invasive Retinal Biomarkers for Early Diagnosis of Alzheimer's Disease.Biomedicines · 2025Review
- Specificity of functional network connectivity during the AD prodromal phase in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.Frontiers in pharmacology · 2025Review
- Construction of a prediction model for Alzheimer's disease using an AI-driven eye-tracking task on mobile devices.Aging clinical and experimental research · 2024Article
- Visual search for real-world scenes in patients with Alzheimer's disease and amnestic mild cognitive impairment.Brain and behavior · 2024Article
- Visual search in Alzheimer's disease and amnestic mild cognitive impairment: An eye-tracking study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Eye movement patterns during viewing face images with neutral expressions in patients with early-stage Alzheimer's disease and amnestic mild cognitive impairment.Brain and behavior · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionVisual search impairment is a potential cognitive marker for Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). The aim of this study is to compare eye movements during visual tracking in AD and aMCI patients versus healthy controls (HCs).
methodsA prospective cohort study included 32 AD and 37 aMCI patients, and 33 HCs. Each participant was asked to look at the target object in a visual stimulus containing one target and eight distractors, and eye movements were recorded with EyeLink 1000 Plus.
resultsAD patients had fewer fixations and shorter target fixation duration than aMCI patients and HCs. Fixation durations were also shorter in aMCI patients compared to HCs. Also, AD patients were more fixated on distractors than HCs. DISCUSSION: Our findings revealed that visual search is impaired in the early stages of AD and even aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum. HIGHLIGHTS: AD patients looked to distractors more and longer than the target compared to aMCI patients and older healthy individuals. aMCI patients had an impaired visual search pattern compared to healthy controls, just like patients with AD. The visual search task differentiated AD and aMCI patients from healthy individuals without dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.