Evidence map›Paper›PMID 37774068›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Low Frequency of Aflatoxin Induced TP53 Gene Codon 249 Mutation in Hepatocellular Carcinoma from Egyptian Patients Living in the Nile Delta Region.

Asmaa Mosbeh, Waleed Abdelmaguid, Sameera Ezzat, Mohamed Kohla, Mervat M Sultan, Mohamed H Abdel-Rahman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Asmaa MosbehDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.
Waleed AbdelmaguidNational Liver Institute Sustainable Sciences Institute Collaborative Research Center, Egypt.
Sameera EzzatDepartment of Public Health, National Liver Institute, Menoufia University, Egypt.
Mohamed KohlaDepartment of Hepatology, National Liver Institute, Menoufia University, Egypt.
Mervat M SultanDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.
Mohamed H Abdel-RahmanDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveStudy the frequency of codon 7 (c.747 G>T, p. R249S) mutation associated with Aflatoxin B1 (AFB1) exposure in Egyptian patients with hepatocellular carcinoma (HCC).

methodsWe utilized restriction fragment polymorphism and direct sequencing to assess codon 7 mutations in 104 hepatocellular carcinomas. The expression of TP53 protein in the tumors were assessed in 44 tumors by a monoclonal rabbit antibody.

resultsWe identified a single 1/104 (1%) with c.747 G>T, p. R249S variant. 28/44 (63.6%) tumors showed no or occasional (less than < 5%) nuclear staining; 9/44 (20.4%) showed mild to moderate (5-49%) and 7/44 (15.9%) showed strong ≥ 50% staining.

conclusionWe observed much lower frequency of TP53 gene than previously published results suggesting geographical alterations in AFB1 exposure in Egypt.

Indexed as

AflatoxinsCarcinoma, HepatocellularLiver NeoplasmsAflatoxin B1AnimalsCodonEgyptGenes, p53HumansMutationRabbitsTumor Suppressor Protein p53Aflatoxin B1AflatoxinsCodonTP53 protein, humanTumor Suppressor Protein p53AflatoxinHepatocellular carcinomaTp53

Identifiers

PMID37774068
PMCPMC10762730
OpenAlexW4387164503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.