Trial reportAmerican journal of respiratory and critical care medicine2023
High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial.
Open access · hybridAbstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase II
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Representation of Hispanic Patients in Clinical Trials for Respiratory Failure: A Systematic Review.Critical care explorations · 2025Pooled it
- Unraveling the impact of nitric oxide, almitrine, and their combination in COVID-19 (at the edge of sepsis) patients: a systematic review.Frontiers in pharmacology · 2023Pooled it
- A safety evaluation of intermittent high-dose inhaled nitric oxide in viral pneumonia due to COVID-19: a randomised clinical study.Scientific reports · 2024Trial
- Differences in the Response to High-Dose Inhaled Nitric Oxide in Self-identified Black and White Individuals: AAmerican journal of respiratory and critical care medicine · 2024Trial
- High-dose inhaled nitric oxide for severe pneumonia caused by multidrug-resistant bacteria: a randomized controlled trial protocol.Annals of medicine · 2026Article
- Beyond vasodilation: reframing inhaled nitric oxide as a precision therapy.American journal of respiratory and critical care medicine · 2026Article
- A Retrospective Analysis of Inhaled Nitric Oxide and Outcomes in Mechanically Ventilated Patients with COVID-19 ARDS.Journal of clinical medicine · 2026Article
- Breath-by-breath quantification of inhaled nitric oxide absorption and modeling of methemoglobin kinetics.Redox biology · 2026Article
- Clinical Application of Inhaled Nitric Oxide in Conditions of Excessive Right Heart Load: A Review from Neonatal Pulmonary Hypertension to Perioperative Cardiac Surgery Management.Journal of cardiovascular development and disease · 2026Review
- The therapeutic potential of high-dose inhaled nitric oxide for antimicrobial effects: a narrative review and future directions.Intensive care medicine experimental · 2026Review
- Inhaled nitric oxide for acute respiratory distress syndrome in adults: a systematic review and meta-analysis.Journal of intensive care · 2026Article
- Physiology-guided management of patients with severe hypoxemia ineligible for ECMO: a multidisciplinary lung rescue team approach.Critical care (London, England) · 2025Observational
- Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review.Patient safety in surgery · 2025Review
- Inhaled nitric oxide for the treatment of COVID-19: an open-label, parallel, randomised controlled trial.ERJ open research · 2025Article
- SARS-CoV-2 (MA10) Infection Aggravates Cerebrovascular Pathology in Endothelial Nitric Oxide Synthase-Deficient Mice.Viruses · 2025Article
- Managing Refractory Hypoxemia in Acute Respiratory Distress Syndrome Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review.Journal of clinical medicine · 2025Review
- Medium-Term Effect of Inhaled Nitric Oxide in Mechanically Ventilated COVID-19 Patients.Journal of clinical medicine · 2025Article
- Nitric Oxide Therapeutics: New Hopes for More Effective Tuberculosis Treatment Combine with Targeted and Controlled Nanotechnology.International journal of nanomedicine · 2025Review
- Nitric Oxide in the Treatment of COVID-19: Nasal Sprays, Inhalants and Nanoparticles.Biochemistry research international · 2025Review
- Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 2 countries.
Raffaele Di FenzaDepartment of Anesthesia, Critical Care, and Pain Medicine.ORCID 0000-0002-5675-7139
Naman S ShettyDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Stefano GianniDepartment of Anesthesia, Critical Care, and Pain Medicine.ORCID 0000-0002-0838-3654
Vibhu ParchaDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Valentina GiammatteoDepartment of Anesthesia, Critical Care, and Pain Medicine.
Bijan Safaee FakhrDepartment of Anesthesia, Critical Care, and Pain Medicine.
Daniel TornbergDepartment of Clinical Sciences and.
Olof WallDepartment of Clinical Sciences and.
Piotr HarbutDepartment of Clinical Sciences and.
Peggy S LaiPulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-9501-8606
Jonathan Z LiHarvard Medical School, Boston, Massachusetts.
Sabrina PaganoniSean M. Healey and AMG Center for ALS.
Stefano CenciDepartment of Anesthesia, Critical Care, and Pain Medicine.
Ariel L MuellerDepartment of Anesthesia, Critical Care, and Pain Medicine.
Timothy T HouleDepartment of Anesthesia, Critical Care, and Pain Medicine.
Oluwaseun AkejuDepartment of Anesthesia, Critical Care, and Pain Medicine.
Edward A BittnerDepartment of Anesthesia, Critical Care, and Pain Medicine.
Somnath BoseHarvard Medical School, Boston, Massachusetts.
Louie K ScottCritical Care Medicine, Department of Medicine, Louisiana State University Health Shreveport, Shreveport, Louisiana.
Ryan W CarrollDivision of Pediatric Critical Care Medicine, Department of Pediatrics.ORCID 0000-0002-7513-7023
Fumito IchinoseDepartment of Anesthesia, Critical Care, and Pain Medicine.
Magnus HedenstiernaDepartment of Infectious Diseases, Danderyd Hospital, Stockholm, Sweden.
Pankaj AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.
Lorenzo BerraDepartment of Anesthesia, Critical Care, and Pain Medicine.ORCID 0000-0003-2702-2093
Nitric Oxide Investigators
Harvard University · USUniversity of Alabama at Birmingham · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USDanderyds sjukhus · SEKarolinska Institutet · SELouisiana State University · US
Funding
Harvard Medical School Vaccine Clinical Trials UnitUM1AI069412 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Lindsey Robert Baden, Daniel R. Kuritzkes · 2012 to 2026
$57.2MNIAID NIH HHS UM1 AI069412
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19Respiratory InsufficiencyAdministration, InhalationAdultHumansNitric OxideRespiration, ArtificialSingle-Blind MethodNitric OxideCOVID-19critical illnessnitric oxidepneumoniarespiration, artificialviremia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.