ArticleIEEE transactions on medical imaging2024
On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.
Article in IEEE transactions on medical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Noninvasive whole-brain imaging of glymphatic dynamics.Science advances · 2026Article
- 3D-PAULM: Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy for Multiparametric Brain and Tumor Imaging.bioRxiv : the preprint server for biology · 2026Article
- Deep computational photoacoustic mesoscopy through heterogeneous tissues enabled by scanning compensation and angular-spectrum enhancement.Photoacoustics · 2026Article
- Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.Placenta · 2026Article
- Low frequency detection in clinical multispectral optoacoustic tomography.Photoacoustics · 2025Article
- Near-infrared-II pulsed laser diode array for spectral photoacoustic imaging of deep tissue oxygenation.Biomedical optics express · 2025Article
- A Comparison of Image Reconstruction Methods for Ring-Array Photoacoustic Computed Tomography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Light and metabolism: label-free optical imaging of metabolic activities in biological systems [Invited].Biomedical optics express · 2025Review
- Advancing precision photothermal therapy by integrating armored gold nanostars with real-time photoacoustic thermometry and imaging.Science advances · 2025Article
- Non-Invasive Deep-Brain Imaging With 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).IEEE transactions on medical imaging · 2025Article
- Three-dimensional diffractive acoustic tomography.Nature communications · 2025Article
- Controlling the sound of light: photoswitching optoacoustic imaging.Nature methods · 2024Review
- Probe fusion all-optic OCT-PAM dual-mode imaging system for biomedical imaging.Photoacoustics · 2024Article
- Deep tissue photoacoustic imaging with light and sound.Npj imaging · 2024Review
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12 authors.
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Abstract
In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets. Low-frequency photoacoustic signal components correspond to slowly varying spatial features and are often omitted during imaging due to the limited detection bandwidth of the ultrasound transducer, or during image reconstruction as undesired background that degrades image contrast. Here we demonstrate that low-frequency photoacoustic signals, in fact, contain functional and molecular information, and can be used to enhance structural visibility, improve quantitative accuracy, and reduce spare-sampling artifacts. We provide an in-depth theoretical analysis of low-frequency signals in PACT, and experimentally evaluate their impact on several representative PACT applications, such as mapping temperature in photothermal treatment, measuring blood oxygenation in a hypoxia challenge, and detecting photoswitchable molecular probes in deep organs. Our results strongly suggest that low-frequency signals are important for functional and molecular PACT.
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