Evidence map›Paper›PMID 37773699›Full record

ArticleImmunity, inflammation and disease2023

The effect of TEMPOL pretreatment on postoperative cognitive function, inflammatory response, and oxidative stress in aged rats under sevoflurane anesthesia.

Tianpin Liu, Tianzi Chen, Jianhua Gong, Changchang You, Bo Zhang, Caiyun Luo, Zhigui Liu, Chun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tianpin LiuDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Tianzi ChenDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Jianhua GongDepartment of Hepatobiliary and Pancreatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Changchang YouDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Bo ZhangDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Caiyun LuoDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Zhigui LiuDepartment of Anesthesiology, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Chun ChenDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.ORCID 0000-0003-4719-233X
China Three Gorges University · CNGuilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe heterocyclic compound 4-hydroxy-(2,2,6,6-Tetramethylpiperidin-1-yl)oxyl (TEMPOL) has a protective effect on neurological function in brain tissues damaged by ischemia and hypoxia. This study explored the effects of TEMPOL pretreatment on postoperative cognitive function in aged rats under sevoflurane anesthesia, focusing on inflammatory response and oxidative stress.

methodsSixty male rats were divided into normal control (C), sevoflurane anesthesia (S), TEMPOL pretreatment (T), and sevoflurane anesthesia + TEMPOL pretreatment (ST) groups (15 per group). Groups T and ST rats received continuous intraperitoneal TEMPOL (100 mg/kg) for 3 days, while groups C and S rats were injected with 0.9% saline. After pretreatment, groups S and ST received 3% sevoflurane anesthesia.

resultsRats in group S exhibited a longer swimming distance, longer escape latency, lower frequency of platform crossing, and shorter dwell time in the targeted quadrant than those in groups C and T. Rats in group ST exhibited a shorter swimming distance, shorter escape latency, higher frequency of platform crossing, and longer dwell time in the targeted quadrant than those in group S. The expressions of interleukin-6, tumor necrosis factor-α, inducible nitric oxide synthase, and Ym1/2 messenger ribonucleic acid were higher in groups S and ST rats than in groups C and T rats and lower in group ST rats than in group S rat (p < .05). Superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-Px) were lower, while malondialdehyde (MDA) was higher in groups S and ST rats than in groups C and T rats (p < .05). Group ST showed higher SOD, T-AOC, and GSH-Px, and lower MDA than group S (p < .05).

conclusionsTEMPOL pretreatment attenuated postoperative cognitive impairment induced by sevoflurane anesthesia in aged rats. This may be attributed to the downregulation of NR2B-CREB-BDNF pathway, reducing the inflammatory response and oxidative stress damage in hippocampal tissue.

Indexed as

AnesthesiaOxidative StressAnimalsCognitionCyclic N-OxidesMaleRatsSevofluraneSpin LabelsSuperoxide DismutaseCyclic N-OxidesSevofluraneSpin LabelsSuperoxide Dismutasetempolaged ratscognitive functioninflammatory responseoxidative stresssevoflurane anesthesiaTEMPOL pretreatment

Identifiers

PMID37773699
PMCPMC10538358
OpenAlexW4387142543

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.