Evidence map›Paper›PMID 37773435›Full record

ArticleEye (London, England)2024

Vitreomacular interface abnormalities in the Ghanaian African.

Winfried M Amoaku, Laura Cushley, Vittorio Silvestri, Stephen Akafo, Kwesi N Amissah-Arthur, Seth Lartey, Courtney N Hageman, Christian M Pappas, William C Hubbard, Paul S Bernstein and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Eye (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Winfried M AmoakuAcademic Ophthalmology, Mental Health & Clinical Neurosciences, University of Nottingham and University Hospitals, Nottingham, UK. wma@nottingham.ac.uk.ORCID 0000-0001-5028-7984
Laura CushleyCentre for Public Health, Queen's University of Belfast, Belfast, UK.
Vittorio SilvestriNICRN, Belfast Health & Social Care Trust, Belfast, UK.
Stephen AkafoUnit of Ophthalmology, Department of Surgery, University of Ghana Medical School, Korle Bu, Accra, Ghana.
Kwesi N Amissah-ArthurUnit of Ophthalmology, Department of Surgery, University of Ghana Medical School, Korle Bu, Accra, Ghana.
Seth LarteyEye Unit, Eye Ear Nose and Throat Department, Komfo Anokye Teaching Hospital and Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Courtney N HagemanDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.
Christian M PappasDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.
William C HubbardDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.
Paul S BernsteinDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-4228-7666
Albert VitaleDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.
Megan RobertsOphthalmology Services, Eye and ENT Clinic, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, UK.
Gianni VirgiliNICRN, Belfast Health & Social Care Trust, Belfast, UK.
Gregory S HagemanDepartment of Ophthalmology & Visual Sciences, Moran Eye Center, Sharon Eccles Steele Center for Translational Medicine, University of Utah, Salt Lake City, UT, USA.
Giuliana SilvestriOphthalmology Services, Eye and ENT Clinic, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, UK.
Ghana AMD Study Group
University of Utah · USUniversity of Ghana · GHBelfast Health and Social Care Trust · GBQueen's University Belfast · GBUniversity of Iowa · USUniversity of Ulster · GBKomfo Anokye Teaching Hospital · GHNottingham University Hospitals NHS Trust · GB

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
NEI NIH HHS P30 EY014800
6 · The paper itself

Abstract

BACKGROUND/

objectiveDescribe vitreomacular interface abnormalities (VMIA) using spectral-domain optical coherence tomography (SD-OCT), and correlations with age-related macular degeneration (AMD) grade in Ghanaian Africans. SUBJECTS/

methodsProspective, cross-sectional study of adults aged ≥50 years recruited in Ghana AMD Study. Participant demographics, medical histories, ophthalmic examination, digital colour fundus photography (CFP) were obtained. High-resolution five-line raster OCT, Macular Cube 512 × 128 scans, and additional line scans in areas of clinical abnormality, were acquired. SD-OCT VMI features classified by International Vitreomacular Traction Study Group system and relationships to AMD grade were evaluated. OUTCOMES: VMIA prevalence, posterior vitreous detachment (PVD), vitreomacular adhesions (VMA), vitreomacular traction (VMT), epiretinal membranes (ERM), correlations with AMD grade.

resultsThe full Ghana AMD cohort included 718 participants; 624 participants (1248 eyes) aged ≥50 years (range = 50-101, mean = 68.8), 68.9% female were included in this analysis. CFP with OCT scans were available for 776 eyes (397 participants); 707 (91.1%) had gradable CFP and OCT scans for both AMD and VMI grading forming the dataset for this report. PVD was absent in 504 (71.3%); partial and complete PVD occurred in 16.7% and 12.0% respectively. PVD did not increase with age (p = 0.720). VMIA without traction and macular holes were observed in 12.2% of eyes; 87.8% had no abnormalities. VMIA was not significantly correlated with AMD grade (p = 0.819).

conclusionsThis provides the first assessment of VMIA in Ghanaian Africans. VMIA are common in Africans; PVD may be less common than in Caucasians. There was no significant association of AMD grade with VMIA.

Indexed as

Eye DiseasesMacula LuteaMacular DegenerationVitreous DetachmentAdultCross-Sectional StudiesFemaleGhanaHumansMaleProspective StudiesRetrospective StudiesTomography, Optical CoherenceVitreous Body

Identifiers

PMID37773435
PMCPMC10858261
OpenAlexW4387169951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.