Evidence map›Paper›PMID 37773254›Full record

ArticleNPJ vaccines2023

mRNA-LNP vaccination-based immunotherapy augments CD8

Ke Qiu, Xing Duan, Minzi Mao, Yao Song, Yufang Rao, Danni Cheng, Lan Feng, Xiuli Shao, Chuanhuan Jiang, Hai Huang and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  20. Neoantigen mRNA vaccines and AHuman vaccines & immunotherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Ke Qiu *Department of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xing Duan *Department of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Minzi Mao *Department of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yao Song *Department of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yufang Rao *Department of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Danni ChengDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Lan FengDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiuli ShaoDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chuanhuan JiangDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Hai HuangDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yan WangResearch Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huifang LiResearch Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0001-7101-0802
Xuemei ChenResearch Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sisi WuResearch Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Dan LuoResearch Core Facility of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Fei ChenDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xingchen PengDepartment of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yongbo ZhengDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Haiyang WangDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jun LiuDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yu ZhaoDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. yutzhao@VIP.163.com.ORCID http://orcid.org/0000-0003-1874-908X
Xiangrong SongDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. songxr@scu.edu.cn.ORCID http://orcid.org/0000-0002-2853-2696
Jianjun RenDepartment of Otolaryngology-Head & Neck Surgery and Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Jianjun.Ren@scu.edu.cn.ORCID http://orcid.org/0000-0002-5938-688X
Sichuan University · CN

Funding

Department of Science and Technology of Sichuan Province (Sichuan Provincial Department of Science and Technology) 2022YFS0066National Natural Science Foundation of China (National Science Foundation of China) 82002868National Natural Science Foundation of China (National Science Foundation of China) 82272777
6 · The paper itself

Abstract

Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how they drive the functional commitment of CD8

Identifiers

PMID37773254
PMCPMC10542330
OpenAlexW4387169923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.