ArticleNature communications2023
Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
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24 citing papers in PubMed, 49 citations in OpenAlex.
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- Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review.Pathogens (Basel, Switzerland) · 2025Review
- Polydopamine Dual-Modal Nanotherapy Synergizes Photothermal Antibacterial and Nanozyme Anti-Inflammatory Effects for Periodontitis Treatment.International journal of nanomedicine · 2025Article
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Corrections and comments
- Update of
Authors and funding
21 authors at 6 institutions in 4 countries.
Yue Huang *Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yuan Liu *Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0213-606X
Nil Kanatha Pandey *Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9116-1488
Shrey ShahDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7037-6845
Aurea Simon-SoroBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3656-6834
Jessica C HsuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3599-2834
Zhi RenBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3553-1958
Zhenting XiangBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dongyeop KimBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6185-9463
Tatsuro ItoBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Min Jun OhBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6082-3162
Christine BuckleyDepartment of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.
Faizan AlawiDepartment of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yong LiBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paul J M SmeetsNorthwestern University Atomic and Nanoscale Characterization Experimental Center, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-7281-0120
Sarah BoyerDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Xingchen ZhaoDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Derk JoesterDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-9663-3309
Domenick T ZeroDepartment of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-7499-2282
David P CormodeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. david.cormode@pennmedicine.upenn.edu.
Hyun KooBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. koohy@upenn.edu.ORCID http://orcid.org/0000-0001-9143-2076
University of Pennsylvania · USNorthwestern University · USIndiana University – Purdue University Indianapolis · USCenter for Innovation · USNihon University · JPUniversidad de Sevilla · ES
Funding
Biofilm Elimination and Caries Prevention using Multifunctional NanocatalystsR01DE025848 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2017 to 2025
$5.6MNorthwestern University Clinical and Translational Science Institute (NUCATS)TL1TR001423 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCCOLLEY, SUSANNA A · 2015 to 2023
$5.0MAcquisition of a K2 Camera for Soft Matter Transmission Electron MicroscopyS10OD026871 · OD · NORTHWESTERN UNIVERSITY · PI GIANNESCHI, NATHAN CLAUDE · 2019 to 2019
$663kAdvanced Training at the Interface of Engineering and Oral-Craniofacial SciencesR90DE031532 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN, STEBE, KATHLEEN J · 2021 to 2025
$505kNCATS NIH HHS TL1 TR001423NIDCR NIH HHS R01 DE025848NIDCR NIH HHS R90 DE031532NIH HHS S10 OD026871
Abstract
Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF
Indexed as
Dental CariesTin FluoridesBiofilmsFerric CompoundsFluoridesHumansSodium FluorideFerric Compoundsferric oxideFluoridesSodium FluorideTin Fluorides
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